Fonseca, Juliane Morais daReis, Adriana Cotta CardosoPereira, Guilherme RochaMoura, Hélia Maria Marques deSouza Filho, José Dias deSilva, Breno de MelloBrandão, Geraldo Célio2023-10-102023-10-102022FONSECA, J. M. da et al. Chromatographic profile of xanthones and flavonoids in the anti-dengue extracts of Fridericia samydoides (Cham.) L.G. Lohmann (Bignoniaceae). Brazilian Journal of Pharmaceutical Sciences, v. 58, artigo e18802, 2022. Disponível em: <https://www.scielo.br/j/bjps/a/WNHFNqnKQF5Z54spJTNCHnS/>. Acesso em: 01 ago. 2023.2175-9790http://www.repositorio.ufop.br/jspui/handle/123456789/17551The flavonoids and xanthones present in the ethanol extracts of leaves and stems of Fridericia samydoides showed that anti-dengue activities in vitro were investigated qualitatively by liquid chromatography–ultraviolet-mass spectrometry in series. Nineteen flavones and fifteen xanthones were detected and characterized on the basis of their fragmentation pattern in the positive and negative ion mode tandem mass spectrometry spectra and ultraviolet bands. Acacetin, chrysin, vitexin, isovitexin, orientin, isoorientin, mangiferin, 2’-O-trans-caffeoylmangiferin, 2’-O-trans-coumaroylmangiferin and 2’-O-trans-cinnamoylmangiferin were identified by comparison with authentic samples. The other compounds detected were tentatively assigned by analysis of the spectral data and by comparison with literature reports. In addition, it performed the fractionation of the leaves extract leading to the isolation of mangiferin, isovitexin and isoorientin. All extracts and isolated compounds inhibited the Dengue virus replication cycle with EC50 less than 25.0 μg/mL for extracts and 272.5, 85.6 and 79.3 μg/mL for mangiferin, isovitexin and isoorientin, respectively.en-USabertoAntiviral activityC-glycosyxanthoneDengue type 2Artigo publicado em periodicoThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: PDF do artigo.https://doi.org/10.1590/s2175-97902022e18802