Caetano, Camila Carla da SilvaCamini, Fernanda CaetanoAlmeida, Letícia TrindadeFerraz, Ariane CoelhoSilva, Tales Fernando daLima, Rafaela Lameira SouzaCarvalho, Mayara Medeiros de FreitasCastro, Thalles de FreitasCarneiro, Cláudia MartinsSilva, Breno de MelloSilva, Silvana de QueirozMagalhães, José Carlos deMagalhães, Cíntia Lopes de Brito2020-05-122020-05-122019CAETANO, C. C. S. et al. Mayaro virus induction of oxidative stress is associated with liver pathology in a non-lethal mouse model. Scientific Reports, v. 9, p. 15289, out. 2019. Disponível em: <https://www.nature.com/articles/s41598-019-51713-9>. Acesso em: 10 fev. 2020.2045-2322http://www.repositorio.ufop.br/handle/123456789/12181Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investigated whether the liver acts as a site of viral replication and if the infection could cause histopathological alterations and an imbalance in redox homeostasis, culminating with oxidative stress. MAYV-infected mice revealed lower weight gain; however, the disease was self-resolving. High virus titre, neutralizing antibodies, and increased levels of aspartate and alanine aminotransferases were detected in the serum. Infectious viral particles were recovered in the liver of infected animals and the histological examination of liver tissues revealed significant increase in the inflammatory infiltrate. MAYV induced significant oxidative stress in the liver of infected animals, as well as a deregulation of enzymatic antioxidant components. Collectively, this is the first study to report that oxidative stress occurs in MAYV infection in vivo, and that it may be crucial in virus pathogenesis. Future studies are warranted to address the alternative therapeutic strategies for Mayaro fever, such as those based on antioxidant compounds.en-USabertoArtigo publicado em periodicoThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Fonte: o próprio artigo.https://doi.org/10.1038/s41598-019-51713-9