Bonomo, Larissa de FreitasSilva, MaísaOliveira, Riva de PaulaSilva, Marcelo EustáquioPedrosa, Maria Lúcia2017-08-142017-08-142012BONOMO, L. de F. et al. Iron overload potentiates diet-induced hypercholesterolemia and reduces liver PPAR-α expression in hamsters. Journal of Biochemical and Molecular Toxicology, v. 26, p. 224-229, 2012. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/jbt.21410/abstract>. Acesso em: 20 de jul. 2017.1099-0461http://www.repositorio.ufop.br/handle/123456789/8528Iron stores and lipids are related to the development of cardiovascular disease. Given that peroxisome proliferator-activated receptor alpha (PPAR-α) regulates important physiological processes that impact lipid and glucose homeostasis, we decided to investigate the effects of iron overload on serum lipids and the liver expression of PPAR-α, 3-hydroxy- 3-methylglutaryl coenzyme A reductase, and cholesterol 7α-hydroxylase. Hamsters were divided into four groups. The standard group (S) was fed the AIN-93M diet, the SI group was fed the diet and iron injections, the hypercholesterolemic group (H) was fed a standard diet containing cholesterol, and the HI group was fed a high-cholesterol diet and iron injections. Serum cholesterol in the HI group was higher than in the H group. Gene expression analysis of PPAR-α showed that the HI group had a lower PPAR-α expression than H. These data show that iron, when associated with a high-fat diet, can cause increased serum cholesterol levels, possibly due to a reduction in PPAR- α expression.en-USrestritoIron overloadCholesteroArtigo publicado em periodicohttp://onlinelibrary.wiley.com/doi/10.1002/jbt.21410/abstracthttps://doi.org/10.1002/jbt.21410