Almeida, Tamires CunhaRibeiro, Luis Henrique GonzagaSantos, Luiza Braga Ferreira dosSilva, Cleiton Moreira daBranquinho, Renata TupinambáLana, Marta deGadelha, Fernanda RamosFátima, Angelo de2019-04-012019-04-012018ALMEIDA, T. C. et al. Synthesis, in vitro and in vivo anti-Trypanosoma cruzi and toxicological activities of nitroaromatic Schiff bases. Biomedicine & Pharmacotherapy, v. 108, p. 1703-1711, dez. 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332218350078?via%3Dihub>. Acesso em: 21 fev. 2019.07533322http://www.repositorio.ufop.br/handle/123456789/10871Chagas disease is a major health problem not only in Latin America but also in Europe and North America due to the spread of this disease into nonendemic areas. In terms of global burden, this major tropical infection is considered to be one of the most neglected diseases, and there are currently only two available chemotherapies: benznidazole and nifurtimox. Unfortunately, although these chemotherapies are beneficial in the acute phase of the disease, benznidazole and nifurtimox lead to significant side effects, including hepatitis and neurotoxicity. Therefore, the search for and development of more effective, safe and inexpensive anti-Trypanosoma cruzi drugs are required. In this work, a series of 10 nitroaromatic Schiff bases bearing different (nitro) aromatic rings-was synthesized. Subsequently, the in vitro and in vivo anti-T. cruzi activities of the Schiff bases were investigated, as well as the in vivo toxicity and the biological effects. The basic structure of the most promising in vivo Schiff base, 10 would be useful in the synthesis of new compounds for Chagas disease treatment.en-USabertoAldiminesProtozoan parasiteTrypanocidal activityChagas diseaseArtigo publicado em periodicoThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Fonte: o próprio artigo.