Lana, Gwenaelle Elza Nathalie PoundGarcia, Giani MartinsTrindade, Izabel CristinaOliveira, Patricia Capelari dePontífice, Thaís GodinhoVilela, José Mário CarneiroAndrade, Margareth SpanglerNottelet, BenjaminPostacchini, Bruna BuenoMosqueira, Vanessa Carla Furtado2019-04-222019-04-222019LANA, G. N. E. P. et al. Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers : probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres. Materials Science and Engineering: C, v. 94, p. 220-233, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0928493118307690>. Acesso em: 7 mar. 2019.0928-4931http://www.repositorio.ufop.br/handle/123456789/11080For best photosensitizer activity phthalocyanine dyes used in photodynamic therapy should be molecularly dispersed. Polyethylene glycol-block-polylactide derivatives presenting benzyl side-groups were synthesized to encapsulate a highly lipophilic phthalocyanine dye (AlClPc) and evaluate the effect of π-π interactions on the nanocarrier colloidal stability and dye dispersion. Copolymers with 0, 1, 2 and 6 mol% of benzyl glycidyl ether (BGE) were obtained via polyethylene glycol initiated ring-opening copolymerization of D,L-lactide with BGE. The block copolymers formed stable, monodisperse nanospheres with low in vitro cytotoxicity. AlClPc loading increased the nanosphere size and affected their colloidal stability. The photo-physical properties of the encapsulated dye, studied in batch and after separation by field flow fractionation, demonstrated the superiority of plain PEG-PLA over BGE-containing copolymers in maintaining the dye in its monomeric (non-aggregated) form in aqueous suspension. High dye encapsulation and sustained dye release suggest that these nanocarriers are good candidates for photodynamic therapy.en-USrestritoDrug nanocarrierBiodegradable polymerAmphiphilic block copolymField flow fractionationArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S0928493118307690