Enhanced mechanical properties, anti-biofilm activity, and cytocompatibility of a methacrylate-based polymer loaded with native multiwalled carbon nanotubes.

Rodrigues, Ricardo Antonio AlpinoSilva, Rosangela Maria Ferreira da Costa eFerreira, Luiza de Almeida QueirozBranco, Natália Tavares TeixeiraÁvila, Érick de SouzaPeres, Anderson MaiaBraga, Weslley FernandesDias, Augusto César SetteAndrade, Ângela LeãoDibb, Regina Guenka PalmaMagalhães, Cláudia Silami deLadeira, Luiz OrlandoSilveira, Rodrigo Richard daMoreira, Allyson NogueiraMartins Júnior, Paulo AntônioYamauti, MônicaDiniz, Ivana Márcia Alves2023-11-172023-11-172022RODRIGUES, R. A. A. et al. Enhanced mechanical properties, anti-biofilm activity, and cytocompatibility of a methacrylate-based polymer loaded with native multiwalled carbon nanotubes. Journal of the Mechanical Behavior of Biomedical Materials, v. 136, artigo 105511, dez. 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1751616122004167>. Acesso em: 01 ago. 2023.1751-6161http://www.repositorio.ufop.br/jspui/handle/123456789/17810Objectives: We aimed to optimize the mechanical and biological properties of a conventional methacrylate-based dental polymer by loading it with double- and triple-walled carbon nanotubes as growth (DTWCNTG). Methods: A formulation of bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate (mass ratio = 2:1) was mixed with DTWCNTG at concentrations of 0.0% (control), 0.001%, 0.005%, and 0.010%. The concentrations were physicochemical and morphologically evaluated, and antibacterial activity was assessed by seeding a Streptococcus mutans strain (ATCC 25175) on the experimental polymeric surfaces. Cellular survival and osteodifferentiation were evaluated in epithelial (HaCat) and preosteoblast cells (MC3T3-E1). Results: The 0.001% DTWCNTG concentration yielded higher compressive strength, elastic modulus, flexural strength, flexural modulus, water sorption, and solubility than the control. The degree of conversion and color did not significantly change with a low amount of DTWCNTG incorporated into the polymer. Antibacterial activity significantly improved when tested on the 0.001% DTWCNTG discs. No groups showed cytotoxicity in a short-term analysis and adding DTWCNTG favored MC3T3-E1 mineralization over the control, particularly in the 0.001% formulation. Significance: The micro-addition of 0.001% DTWCNTG confers mechanical resistance, antimicrobial properties, and bioactivity to methacrylate-based polymers without significantly compromising color. Incorporating DTWCNTG improved dental composite properties and could be a biomodified material for minimally invasive procedures.en-USrestritoMultiwalled carbon nanotubesMethacrylate-based polymersDental resin compositesAntibacterial activityBiomodificationEnhanced mechanical properties, anti-biofilm activity, and cytocompatibility of a methacrylate-based polymer loaded with native multiwalled carbon nanotubes.Artigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S1751616122004167https://doi.org/10.1016/j.jmbbm.2022.105511