Guerra, Joyce Ferreira da CostaMaciel, Poliane SilvaAbreu, Isabel Cristina Mallosto Emerich dePereira, Renata RebecaSilva, MaísaCardoso, Leandro de MoraisSant'Ana, Helena Maria PinheiroLima, Wanderson Geraldo deSilva, Marcelo EustáquioPedrosa, Maria Lúcia2016-01-262016-01-262015GUERRA, J. F. da C. Dietary açai attenuates hepatic steatosis via adiponectin-mediated effects on lipid metabolism in high-fat diet mice. Journal of Functional Foods, v. 14, p. 192-202, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1756464615000298>. Acesso em: 15 out. 2015.1756-4646http://www.repositorio.ufop.br/handle/123456789/6231Polyphenols, especially anthocyanins, have been considered promising for the prevention of nonalcoholic fatty liver disease (NAFLD). This study investigated whether açai (Euterpe oleracea Mart.), a source of anthocyanins and recognized as one of the new “superfruits”, could alleviate high-fat diet (HFD)-induced NAFLD in mice. In HFD mice, aqueous açai extract (AAE) administration (3 g/kg) for six weeks improved insulin resistance index and increased adiponectin mRNA expression in adipose tissue and serum levels. Furthermore, AAE decreased the total liver triacylglycerol content and attenuated HFD-induced hepatic steatosis. This reduced hepatic lipid content was associated with AAE-mediated up-regulation of genes involved in adiponectin signaling, including adiponectin receptor 2, PPAR-α, and its target gene, carnitine palmitoyltransferase. Thus, dietary açai can protect liver from steatosis through its enhancement of adiponectin levels, improvement of insulin sensitivity, and increase in PPAR-α-mediated fatty acid oxidation.en-USEuterpe oleracea martPeroxisome proliferator-activatedNonalcoholic fatty liver diseaseArtigo publicado em periodicoO periódico Journal of Functional Foods concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3736991281944.https://doi.org/10.1016/j.jff.2015.01.025