Cangussú, Silvia DantasSouza, Carolina Carvalho deCampos, Camila FrançaVieira, Leda QuerciaAfonso, Luís Carlos CroccoArantes, Rosa Maria Esteves2015-03-032015-03-032009CANGUSSÚ, S. D. et al. Histopathology of Leishmania major infection: revisiting L. major histopathology in the ear dermis infection model. Memórias do Instituto Oswaldo Cruz, v. 104, p. 918-922, 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600017&lng=en&nrm=iso&tlng=en>. Acesso em: 08 nov. 2014.0074-0276http://www.repositorio.ufop.br/handle/123456789/4523We describe the relationship between lesion outcome and histopathological hallmarks in susceptible (BALB/c) and resistant (C57BL/6 and IL-4-deficient BALB/c) mouse strains over the course of a 12-week-infection with Leishmania major in the ear. The infiltration of mononuclear cells and polymorphonuclear cells occurred within 6 h and mononuclear cells predominated one week post-infection. Permissive intracellular growth of the pathogen was associated with non-healing lesions. In contrast, tissue damage and clearance of the parasite was observed in healing lesions and was associated with inducible nitric oxide synthase expression. The identification of the struc¬tural components of tissue reaction to the parasite in this study furthers our understanding of subjacent immune effector mechanisms.en-USLeishmania majorInfectious skin diseasesPathologyHistopathology of Leishmania major infection : revisiting L. major histopathology in the ear dermis infection model.Artigo publicado em periodicoO periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12 dez. 2013.http://dx.doi.org/10.1590/S0074-02762009000600017