Amaral, Ricardo GuimarãesGomes, Silvana Vieira FlorestaAndrade, Luciana NaloneSantos, Sara Albuquerque dosSeverino, PatríciaAlbuquerque Júnior, Ricardo Luiz Cavalcanti deSouto, Eliana B.Brandão, Geraldo CélioSantos, Sandra LautonDavid, Jorge MauricioCarvalho, Adriana Andrade2021-12-062021-12-062020AMARAL, R. G. et al. Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract. Molecules, v. 25, p. 4814, 2020. Disponível em: <https://www.mdpi.com/1420-3049/25/20/4814>. Acesso em: 10 jun. 2021.1420-3049http://www.repositorio.ufop.br/jspui/handle/123456789/14092Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.en-USabertoNatural productsCancerArtigo publicado em periodicoThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Fonte: o PDF do artigo.https://doi.org/10.3390/molecules25204814