Machado Júnior, Pedro AlvesAraújo, Natália Pereira da SilvaSouza, Ana Beatriz Farias deCastro, Thalles de FreitasOliveira, Michel Ângelo das Graças SilvaCosta, Guilherme de PaulaMatos, Natália Alves deVieira, Paula Melo de AbreuSilva, André Talvani Pedrosa daBezerra, Frank SilvaCangussú, Silvia Dantas2021-09-232021-09-232020MACHADO JÚNIOR, P. A. et al. Protective effects of quercetin on livers from mice exposed to long-term cigarette smoke. Biomed Research International, v. 2020, article ID 2196207, nov. 2020. Disponível em: <https://www.hindawi.com/journals/bmri/2020/2196207/>. Acesso em: 10 jun. 2021. 2314-6141http://www.repositorio.ufop.br/jspui/handle/123456789/13786Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure.en-USabertoArtigo publicado em periodicoThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o PDF do artigo.https://doi.org/10.1155/2020/2196207