Neuroendocrine apendicopathy in morphologically normal appendices of patients with diagnosis of acute appendicitis : diagnostic study.

dc.contributor.authorPetroianu, Andy
dc.contributor.authorBarroso, Thiago Vinicius Villar
dc.contributor.authorBuzelin, Marcelo Araújo
dc.contributor.authorTheobaldo, Bárbara de Melo
dc.contributor.authorTafuri, Luciene Simões de Assis
dc.date.accessioned2021-12-06T17:22:19Z
dc.date.available2021-12-06T17:22:19Z
dc.date.issued2020pt_BR
dc.description.abstractBackground: About 15%–25% of appendices removed to treat acute appendicitis present normal macro- and macroscopic morphology. The objective of this study was to verify an association of proinflammatory, neuro endocrine and immune mediators with morphologically normal appendices removed from patients with clinical laboratorial and imaging characteristics of acute appendicitis. Materials and methods: Appendices removed from 121 adult patients of both genders were distributed into three groups according to their following characteristics: group 1: 53 macro- and microscopically normal appendices from patients with clinical, laboratorial and imaging diagnosis of acute appendicitis; group 2: 24 inflamed appendices from patients with clinical, laboratorial, imaging and histopathological diagnosis of acute appendi citis; group 3: 44 normal appendices from patients submitted to right colectomy to treat localized ascending colon adenocarcinoma. All appendices were immunohistochemically studied for gastrin inhibitor peptide, mast cell tryptase, vascular endothelial growth factor; intestinal vasoactive peptide, tumor necrosis factor alpha, interleukin 1, prostaglandin E2, gene-protein product 9.5, CD8 T lymphocytes, synaptophysine, enolase, and S100 protein. Results: The group 1 revealed increased levels of synaptophysine, enolase, mast cell tryptase and PGP-9.5 comparing with the other two groups. The group 2 presented increased levels of interleukin 1, CD8 T lympho cytes and prostaglandin E2 comparing with the other two groups. The group 3 confirmed the normal levels of all these neuroendocrine, immune and proinflammatory mediators. Conclusions: Morphologically normal appendices removed from patients with clinical and complementary exams indicating acute appendicitis have appendicular neuroimmunoendocrine disorder associated with the mediators synaptophysin, enolase, mast cell-related tryptase and gene-protein product 9.5.pt_BR
dc.identifier.citationPETROIANU, A. et al.Neuroendocrine apendicopathy in morphologically normal appendices of patients with diagnosis of acute appendicitis: diagnostic study. Annals of Medicine and Surgery, v. 60, p. 344-351, 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S204908012030399X>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.amsu.2020.10.044pt_BR
dc.identifier.issn2049-0801
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14076
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Fonte: o PDF do artigo.pt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectHistologypt_BR
dc.titleNeuroendocrine apendicopathy in morphologically normal appendices of patients with diagnosis of acute appendicitis : diagnostic study.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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