Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats.
dc.contributor.author | Custódio, Carlos Henrique Xavier | |
dc.contributor.author | Miranda, José Rodolfo Rubini | |
dc.contributor.author | Yamaguchi, Juliana | |
dc.contributor.author | Silveira, Kátia Daniela da | |
dc.contributor.author | Teixeira, Mauro Martins | |
dc.contributor.author | Chianca Júnior, Deoclécio Alves | |
dc.contributor.author | Silva, Ana Cristina Simões e | |
dc.contributor.author | Santos, Robson Augusto Souza dos | |
dc.contributor.author | Camargo, Antônio Carlos Martins de | |
dc.contributor.author | Ianzer, Danielle Alves | |
dc.date.accessioned | 2017-11-27T16:07:42Z | |
dc.date.available | 2017-11-27T16:07:42Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Proline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/ kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1– 43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj- PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Δ = −13 to −24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal functi | pt_BR |
dc.identifier.citation | XAVIER, C. H. et al. Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats. International Journal of Peptide Research And Therapeutics, v. 25, p. 1-5, 2017. Disponível em: <https://link.springer.com/article/10.1007/s10989-017-9575-7>. Acesso em: 15 set. 2017. | pt_BR |
dc.identifier.doi | https://doi.org/10.1007/s10989-017-9575-7 | |
dc.identifier.issn | 1573-3904 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/9187 | |
dc.identifier.uri2 | https://link.springer.com/article/10.1007/s10989-017-9575-7 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Blood pressure | pt_BR |
dc.subject | Heart rate | pt_BR |
dc.subject | Hypertension | pt_BR |
dc.subject | Prolinerich oligopeptides | pt_BR |
dc.subject | Renal function | pt_BR |
dc.title | Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |