Anti-inflammatory, antimicrobial, antioxidant and photoprotective investigation of red propolis extract as sunscreen formulation in polawax cream.
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2023
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Many activities have been described for propolis, including, antiviral, antibacterial, antifungal, anti-inflammatory, immunoregulatory, antioxidant and wound healing properties. Recently,
propolis has been highlighted due to its potential application in the pharmaceutical and cosmetic
industries, motivating a better understanding of its antioxidant and anti-inflammatory activities.
Propolis and its main polyphenolic compounds presented high antioxidant activity, and effectiveness
as broad spectrum UVB and UVA photoprotection sunscreens. Through a qualitative phytochemical
screening, the ethanolic red propolis extracts (EEPV) (70% at room temperature and 70% at a hot
temperature) presented a positive result for flavonoids and terpenoids. It presented an antioxidant
activity for reducing 50% of DPPH of 17 and 12 µg/mL for extraction at room temperature and
at a hot temperature, respectively. The UPLC-QTOF-MS/MS analysis allowed the annotation of
40 substances for EEPV-Heated and 42 substances for EEPV-Room Temperature. The IC50 results
of the ABTS scavenging activity was 4.7 µg/mL for both extractions, at room temperature and at a
hot temperature. Additionally, we also evaluated the cytotoxic profile of propolis extracts against
macrophage (RAW 264.7 cells) and keratinocytes (HaCaT cells), which showed non-cytotoxic doses
in cell viability assays even after a long period of exposure. In addition, propolis extracts showed
antibacterial activity for Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis),
demonstrating potential biological activity for the creation of formulations aimed at disease control
and prevention.
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Red propolis, Photoprotective, Antioxidant, Ethanolic extracts, Anti-inflammatory
Citação
VALVERDE, T. M. et al. Anti-inflammatory, antimicrobial, antioxidant and photoprotective investigation of red propolis extract as sunscreen formulation in polawax cream. International Journal of Molecular Sciences, v. 24, n. 6, artigo 5112, 2023. Disponível em: <https://www.mdpi.com/1422-0067/24/6/5112>. Acesso em: 01 ago. 2023.