Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon.

dc.contributor.authorMelo, Luísa Helena Perin de
dc.contributor.authorFonseca, Kátia da Silva
dc.contributor.authorCarvalho, Thaís Vieira de
dc.contributor.authorCarvalho, Lívia Mendes
dc.contributor.authorMadeira, João Vitor
dc.contributor.authorMedeiros, Luciana da Fonseca
dc.contributor.authorMolina, Israel
dc.contributor.authorOliveira, Rodrigo Corrêa de
dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorVieira, Paula Melo de Abreu
dc.date.accessioned2020-04-28T14:53:02Z
dc.date.available2020-04-28T14:53:02Z
dc.date.issued2020
dc.description.abstractStudies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosoma cruzi Y strain in the acute and chronic phases of Chagas' disease. Our findings indicate that an experimental treatment with a BNZ low-dose (40 mg/kg/day) is similarly effective as the usual dose in the chronic mice model (100% of cure). In addition, the treatment in the chronic model of Chagas' disease presented better results than the acute model and colon appears to be a key tissue when it comes to evaluating treatment efficacy compared to blood and heart. Therefore, our data suggest the reconsideration of the current therapy, mainly in the chronic phase of the disease.pt_BR
dc.identifier.citationMELO, L. H. P. et al. Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon. Experimental Parasitology, v. 210, p. 107834, mar. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S001448941930503X?via%3Dihub>. Acesso em: 10 fev. 2020.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.exppara.2020.107834pt_BR
dc.identifier.issn0902-449
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/12116
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S001448941930503X?via%3Dihubpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectTreatmentpt_BR
dc.titleLow-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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