The dengue virus nonstructural protein 1 (NS1) increases NF-kB transcriptional activity in HepG2 cells.
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2011
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Dengue virus nonstructural protein 1 (NS1) is a
glycoprotein involved in viral RNA replication. NS1
associates with host cell proteins and can be found in lipid
raft domains on the host cell surface, suggesting an
involvement in signal transduction events. In this work, we
observed that NS1 expression in HepG2 cells increases
nuclear translocation of NF-jB p65 protein, which was
paralleled by DNA-protein complex formation. Luciferase
assays showed an increase in NF-jB transcriptional
activities in NS1-expressing cells when compared to
parental cells. NS1 may enhance NF-jB function in host
cells and contribute to the pathogenesis of dengue.
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SILVA, B. M. et al. The dengue virus nonstructural protein 1 (NS1) increases NF-kB transcriptional activity in HepG2 cells. Archives of Virology , v. 156, p. 1275-1279, 2011. Disponível em: <http://link.springer.com/article/10.1007/s00705-011-0969-0>. Acesso em: 19 fev. 2017.