Update on rapid diagnostics for covid-19 : a systematic review.
Nenhuma Miniatura disponível
Data
2022
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
An accurate and rapid diagnosis of COVID-19 is an effective strategy for pandemic control,
allowing disease screening and timely therapeutic intervention. We analyzed scientific reports about
rapid tests for the diagnosis of COVID-19 to assess their reliability parameters. Medical Subject
Headings terms or keywords related to point-of-care and rapid diagnostic testing for SARS-CoV-2
and COVID-19 were searched in data published from November 2020 to November 2021 in PubMed
and Google Scholar databases. Notable differences were observed in sensitivity among direct tests
that used different samples, and good accuracy was reported in a significant number of studies
(>80%). Pediatric samples and samples with high Ct values (RT-PCR) had suboptimal sensitivity
(range 45.4% to 66%). Further, a lack of sensitivity (<46.2%) was observed in point-of-care tests and in
rapid diagnostic tests for antibody detection in the first days after infection, with increasing values
in postinfection analysis (>60%). For serological detection of IgM or Antigen rapid diagnostic tests,
no cross-reactivity was found with other coronaviruses. Therefore, although these tests are very
important in facing the pandemic, they still need to be improved to test cross-reactivity against other
pathogens, especially against other coronaviruses.
Descrição
Palavras-chave
SARS-CoV-2, Point-of-care, Rapid diagnostic tests
Citação
DIAS, B. de P. et al. Update on rapid diagnostics for covid-19 : a systematic review. International Journal of Translational Medicine, v. 2, n. 2, p. 252-274, 2022. Disponível em: <https://www.mdpi.com/2673-8937/2/2/23>. Acesso em: 01 ago. 2023.