Equisetum hyemale‑derived unprecedented bioactive composite for hard and soft tissues engineering.
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2022
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Although Bioactive Glasses (BGs) have been progressively optimized, their preparation often still
involves the use of toxic reagents and high calcination temperatures to remove organic solvents.
In the present work, these synthesis related drawbacks were overcome by treating the ashes from
the Equisetum hyemale plant in an ethanol/water solution to develop a bioactive composite [glass/
carbon (BG-Carb)]. The BG-Carb was characterized by scanning electron microscopy, and transmission
electron microscopy; and its chemical composition was assessed by inductively coupled plasmaoptical emission spectroscopy. Brunauer–Emmett–Teller gas adsorption analysis showed a specifc
surface area of 121 m2
g−1. The formation of hydroxyapatite (HA) surface layer in vitro was confrmed
by Fourier-transform infrared spectroscopy analysis before and after immersion in simulated
body fuid (SBF) solution. The Rietveld refnement of the XRD patterns and selected area electron
difraction analyses confrmed HA in the sample even before immersing it in SBF solution. However,
stronger evidences of the presence of HA were observed after immersion in SBF solution due to the
surface mineralization. The BG-Carb samples showed no cytotoxicity on MC3T3-E1 cells and osteodiferentiation capacity similar to the positive control. Altogether, the BG-Carb material data reveals a
promising plant waste-based candidate for hard and soft tissue engineering.
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SILVA, R. M. F. da C. e et al. Equisetum hyemale‑derived unprecedented bioactive composite for hard and soft tissues engineering. Scientific Reports, v. 12, artigo 13425, 2022. Disponível em: <https://www.nature.com/articles/s41598-022-17626-w>. Acesso em: 15 mar. 2023.