Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis : development, characterization, and ocular biocompatibility.
dc.contributor.author | Cardoso, Jéssica Ferreira | |
dc.contributor.author | Perasoli, Fernanda Barçante | |
dc.contributor.author | Almeida, Tamires Cunha | |
dc.contributor.author | Marques, Maria Betânia de Freitas | |
dc.contributor.author | Toledo, Cibele Rodrigues | |
dc.contributor.author | Gil, Priscilla Oliveira | |
dc.contributor.author | Tavares, Harley da Silva | |
dc.contributor.author | Paz, Mariana Campos da | |
dc.contributor.author | Mussel, Wagner da Nova | |
dc.contributor.author | Magalhães, Juliana Texeira | |
dc.contributor.author | Silva, Glenda Nicioli da | |
dc.contributor.author | Cunha Júnior, Armando da Silva | |
dc.contributor.author | Granjeiro, Paulo Afonso | |
dc.contributor.author | Klibanov, Alexander M. | |
dc.contributor.author | Silva, Gisele Rodrigues da | |
dc.date.accessioned | 2021-09-13T18:40:09Z | |
dc.date.available | 2021-09-13T18:40:09Z | |
dc.date.issued | 2021 | pt_BR |
dc.description.abstract | Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid (VCMDMPEI nanoparticles/HA) were synthesized as an adjuvant for the treatment of bacterial endophthalmitis. The nanoparticles were formulated by experimental statistical design, thoroughly characterized, and evaluated in terms of bactericidal activity and both in vitro and in vivo ocular biocompatibility. The VCM-DMPEI nanoparticles/HA were 154 ± 3 nm in diameter with a 0.197 ± 0.020 polydispersity index; had a + 26.4 ± 3.3 mV zeta potential; exhibited a 93% VCM encapsulation efficiency; and released 58% of the encapsulated VCM over 96 h. VCM and DMPEI exhibited a synergistic bactericidal effect. The VCM-DMPEI nanoparticles/HA were neither toxic to ARPE-19 cells nor irritating to the chorioallantoic membrane. Moreover, the VCM-DMPEI nanoparticles/HA did not induce modifications in retinal functions, as determined by electroretinography, and in the morphology of the ocular tissues. In conclusion, the VCM-DMPEI nanoparticles/HA may be a useful therapeutic adjuvant to treat bacterial endophthalmitis. | pt_BR |
dc.identifier.citation | CARDOSO, J. F. et al. Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis: development, characterization, and ocular biocompatibility. International Journal of Biological Macromolecules, v. 169, p. 330-341, 2021. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0141813020352156>. Acesso em: 10 jun. 2021. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.ijbiomac.2020.12.057 | pt_BR |
dc.identifier.issn | 0141-8130 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/13704 | |
dc.identifier.uri2 | https://www.sciencedirect.com/science/article/abs/pii/S0141813020352156 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.title | Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis : development, characterization, and ocular biocompatibility. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
Arquivos
Pacote Original
1 - 1 de 1
Nenhuma Miniatura disponível
- Nome:
- ARTIGO_VancomycinLoadedDodecyl.pdf
- Tamanho:
- 1.93 MB
- Formato:
- Adobe Portable Document Format
- Descrição:
Licença do Pacote
1 - 1 de 1
Nenhuma Miniatura disponível
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição: