High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil.
dc.contributor.author | Pereira, Anna Carolina Toledo da Cunha | |
dc.contributor.author | Siqueira, Tatiane Ribeiro de | |
dc.contributor.author | Prado, Andressa Anunciação de Oliveira | |
dc.contributor.author | Silva, Camila Almeida Veiga da | |
dc.contributor.author | Moraes, Thaís de Fátima Silva | |
dc.contributor.author | Aleixo, Alan Alex | |
dc.contributor.author | Magalhães, José Carlos de | |
dc.contributor.author | Souza, Gabriel Augusto Pires de | |
dc.contributor.author | Drumond, Betânia Paiva | |
dc.contributor.author | Ferreira, Gustavo Portela | |
dc.contributor.author | Silva, Breno de Mello | |
dc.contributor.author | Magalhães, Cíntia Lopes de Brito | |
dc.contributor.author | Santos, Luciana Lara | |
dc.contributor.author | Ferreira, Jaqueline Maria Siqueira | |
dc.contributor.author | Malaquias, Luiz Cosme Cotta | |
dc.contributor.author | Coelho, Luiz Felipe Leomil | |
dc.date.accessioned | 2018-05-03T14:36:32Z | |
dc.date.available | 2018-05-03T14:36:32Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Dengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil. A total of 1560 individuals were genotyped for polymorphisms in DC-SIGN (rs4804803), FcγRIIa (rs1801274), VDR (rs7975232), and TNF-α (rs1800629). The presence of anti-dengue antibodies (IgM and/or IgG) in these samples was also assayed. Anti-dengue antibodies were detected at an overall frequency of 16.86%, indicating a virus infection in asymptomatic individuals. The genotypic frequencies of all SNPs studied did not differ between the asymptomatic and control groups. Regarding the allelic frequencies of the four SNPs analyzed, a higher frequency was detected of the G allele of FcγRIIa/rs1801274 in the asymptomatic individuals when compared to that in the control group (p =0.03). Therefore, the results showed a high prevalence of asymptomatic individuals in Minas Gerais State, with a potential association between the presence of the G allele of FcγRIIa/rs1801274 and protection against symptomatic disease. | pt_BR |
dc.identifier.citation | PEREIRA, A. C. T. da C. et al. High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil. Immunogenetics, vol. 1, p. 1-8, 2017. Disponível em: <https://link.springer.com/article/10.1007%2Fs00251-017-1046-y>. Acesso em: 05 abr. 2018. | pt_BR |
dc.identifier.issn | 14321211 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/9892 | |
dc.identifier.uri2 | https://link.springer.com/article/10.1007%2Fs00251-017-1046-y | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Dengue | pt_BR |
dc.subject | Asymptomatic patients | pt_BR |
dc.title | High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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