Schistosoma mansoni : egg-induced downregulation of hepatic stellate cell activation and fibrogenesis.
dc.contributor.author | Anthony, Barrie | |
dc.contributor.author | Mathieson, William | |
dc.contributor.author | Borges, William de Castro | |
dc.contributor.author | Allen, Jeremy | |
dc.date.accessioned | 2015-03-16T18:53:30Z | |
dc.date.available | 2015-03-16T18:53:30Z | |
dc.date.issued | 2010 | |
dc.description.abstract | Eggs of Schistosoma mansoni trapped in human liver can lead to fibrosis. Since liver fibrosis requires activation of hepatic stellate cells (HSC) from a quiescent to a myofibroblastic phenotype, we investigated the effects of S. mansoni eggs on this process using in vitro co-cultures with human HSC and evaluated established biomarkers for activation and fibrosis. HSC demonstrate significantly reduced expression of a-smooth muscle actin (p < 0.001), connective tissue growth factor (p < 0.01) and type I collagen (p < 0.001) but significantly increased expression of peroxisome proliferator-activated receptor-c (p < 0.01). Morphologically, HSC exhibited elongated fine cellular processes and reduced size, increased accumulation of lipid droplets and reduced expression and organization of a-smooth muscle actin and F-actin stress fibres. Additionally, schistosome eggs prevented the HSC fibrogenic response to exogenous transforming growth factor-b. In summary, schistosome eggs blocked fibrogenesis in HSC, a finding which may have implications for our understanding of the fibrotic pathology in S. mansoni infections. | pt_BR |
dc.identifier.citation | ANTHONY, B. et al. Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis. Experimental Parasitology, v. 124, p. 409-420, 2010. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0014489409003452>. Acesso em: 08 nov. 2014. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.exppara.2009.12.009 | |
dc.identifier.issn | 0014-4894 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/4651 | |
dc.language.iso | en_US | pt_BR |
dc.rights.license | O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3550940313825. | pt_BR |
dc.subject | Schistosomes | pt_BR |
dc.subject | Liver fibrosis | pt_BR |
dc.subject | Relative gene expression | pt_BR |
dc.subject | Immunocytochemistry | pt_BR |
dc.subject | Trematodes | pt_BR |
dc.title | Schistosoma mansoni : egg-induced downregulation of hepatic stellate cell activation and fibrogenesis. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
Arquivos
Pacote Original
1 - 1 de 1
Nenhuma Miniatura disponível
- Nome:
- ARTIGO_SchistosomamansoniEgg.pdf
- Tamanho:
- 5.95 MB
- Formato:
- Adobe Portable Document Format
Licença do Pacote
1 - 1 de 1
Nenhuma Miniatura disponível
- Nome:
- license.txt
- Tamanho:
- 2.57 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição: