Nanoparticles as vaccines to prevent arbovirus infection : a long road ahead.

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dc.contributor.authorSouza, Gabriel Augusto Pires de
dc.contributor.authorRocha, Raíssa Prado
dc.contributor.authorGonçalves, Ricardo Lemes
dc.contributor.authorFerreira, Cyntia Silva
dc.contributor.authorSilva, Breno de Mello
dc.contributor.authorCastro, Renato Fróes Goulart de
dc.contributor.authorRodrigues, João Francisco Vitório
dc.contributor.authorVieira Júnior, João Carlos Vilela
dc.contributor.authorMalaquias, Luiz Cosme Cotta
dc.contributor.authorAbrahão, Jônatas Santos
dc.contributor.authorCoelho, Luiz Felipe Leomil
dc.date.accessioned2021-09-27T15:28:33Z
dc.date.available2021-09-27T15:28:33Z
dc.date.issued2021pt_BR
dc.description.abstractArthropod-borne viruses (arboviruses) are a significant public health problem worldwide. Vaccination is considered one of the most effective ways to control arbovirus diseases in the human population. Nanoparticles have been widely explored as new vaccine platforms. Although nanoparticles’ potential to act as new vaccines against infectious diseases has been identified, nanotechnology’s impact on developing new vaccines to prevent arboviruses is unclear. Thus, we used a comprehensive bibliographic survey to integrate data concerning the use of diverse nanoparticles as vaccines against medically important arboviruses. Our analysis showed that considerable research had been conducted to develop and evaluate nanovaccines against Chikungunya virus, Dengue virus, Zika virus, Japanese encephalitis virus, and West Nile virus. The main findings indicate that nanoparticles have great potential for use as a new vaccine system against arboviruses. Most of the studies showed an increase in neutralizing antibody production after mouse immunization. Nevertheless, even with significant advances in this field, further efforts are necessary to address the nanoparticles’ potential to act as a vaccine against these arboviruses. To promote advances in the field, we proposed a roadmap to help researchers better characterize and evaluate nanovaccines against medically important arboviruses.pt_BR
dc.identifier.citationSOUZA, G. A. P. de et al. Nanoparticles as vaccines to prevent arbovirus infection: a long road ahead. Pathogens, v. 10, n. 36, 2021. Disponível em: <https://www.mdpi.com/2076-0817/10/1/36>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.3390/pathogens10010036pt_BR
dc.identifier.issn 2076-0817
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13815
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: o PDF do artigo.pt_BR
dc.subjectExperimental roadmappt_BR
dc.titleNanoparticles as vaccines to prevent arbovirus infection : a long road ahead.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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