Cytotoxic activity of butanolic extract from Sambucus nigra L. flowers in natura and vehiculated in micelles in bladder cancer cells and fibroblasts.

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dc.contributor.authorPereira, Deise Inocêncio
dc.contributor.authorAmparo, Tatiane Roquete
dc.contributor.authorAlmeida, Tamires Cunha
dc.contributor.authorCosta, Fernanda Senna Ferreira
dc.contributor.authorBrandão, Geraldo Célio
dc.contributor.authorSantos, Orlando David Henrique dos
dc.contributor.authorSilva, Glenda Nicioli da
dc.contributor.authorSouza, Gustavo Henrique Bianco de
dc.date.accessioned2021-09-13T18:07:50Z
dc.date.available2021-09-13T18:07:50Z
dc.date.issued2020pt_BR
dc.description.abstractBladder cancer has a high incidence and recurrence rate among patients worldwide. This study aimed to evaluate the cytotoxic activity of fractions of Sambucus nigra L. flower extracts on bladder carcinoma cells (T24 cells) and human fibroblast cells (MRC-5). The butanolic fraction (F-BuOH) was characterized by UPLC-DADMS/MS and nine flavonoids were identified. Rutin was the major compound. The cytotoxic activity of this fraction was observed in the T24 cells but not in MRC-5 cells, indicating selectivity. F-BuOH was incorporated in micellar solutions of PluronicVR F127 and cytotoxic effect for T24 cells was observed again. In vitro assay demonstrated a controlled release of the fraction from the micelles. The results obtained showed that flavonoids are the possible responsible for cytotoxic activity in bladder carcinoma cells. In addition, micellar solutions act together to increase the action of the butanolic fraction.pt_BR
dc.identifier.citationPEREIRA, D. I. et al. Cytotoxic activity of butanolic extract from Sambucus nigra L. flowers in natura and vehiculated in micelles in bladder cancer cells and fibroblasts. Natural Product Research, nov. 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1851220?journalCode=gnpl20>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1080/14786419.2020.1851220pt_BR
dc.identifier.issn1478-6427
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13698
dc.identifier.uri2https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1851220?journalCode=gnpl20pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectFlavonoidspt_BR
dc.subjectPolymeric micellespt_BR
dc.subjectPluronicpt_BR
dc.titleCytotoxic activity of butanolic extract from Sambucus nigra L. flowers in natura and vehiculated in micelles in bladder cancer cells and fibroblasts.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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