Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae).
dc.contributor.author | Pimenta, Adriano Monteiro de Castro | |
dc.contributor.author | Eauclaire, Marie France Martin | |
dc.contributor.author | Rochat, Hervé | |
dc.contributor.author | Figueiredo, Suely Gomes de | |
dc.contributor.author | Kalapothakis, Evanguedes | |
dc.contributor.author | Afonso, Luís Carlos Crocco | |
dc.contributor.author | Lima, Maria Elena de | |
dc.date.accessioned | 2015-03-12T18:54:27Z | |
dc.date.available | 2015-03-12T18:54:27Z | |
dc.date.issued | 2001 | |
dc.description.abstract | We report here the isolation by a two-step chromatographic procedure of two new toxins from the South American scorpion Tityus bahiensis. Their amino-acid sequences and some of their biological features were established. The two toxins have different biological properties. Toxin TbIT-I had almost no activity or pharmacological effects in vertebrate tissues whereas it was lethal to house ¯ies (LD50 80.0 ng/house ¯y). In contrast, Tb2-II was active against both mammals (intracerebroventricular injection of 100 ng/mouse was lethal) and insects (LD50 40.0 ng/house ¯y). The amino-acid sequences of these toxins were established and found to be similar (60±95%) to previously described b-toxins from the Tityus genus. Based on the available comparative information, this study attempts identify possible structure±function relationships that may be responsible for the differences in bioactivity displayed by these toxins. | pt_BR |
dc.identifier.citation | PIMENTA, A. M. de C. et al. Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae). Toxicon, v. 39, p. 1009-1019, 2001. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0041010100002403>. Acesso em: 08 nov. 2014. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/S0041-0101(00)00240-3 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/4617 | |
dc.language.iso | en_US | pt_BR |
dc.rights.license | O periódico Toxicon concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3530901439097. | pt_BR |
dc.subject | Tityus bahiensis | pt_BR |
dc.subject | Toxin | pt_BR |
dc.subject | Anti-insect activity | pt_BR |
dc.subject | Three-dimensional models | pt_BR |
dc.title | Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae). | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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