Antiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) extracts and constituents.
Carregando...
Data
2017
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
A phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro
assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus
(EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1,
and VACV-WRwith best results for the fruits extract against DENV-2 (SI > 38.2). For VACV-WRand HSV-1, EC50 values > 200 𝜇g
mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and
identified as the C-glucosylxanthones mangiferin (1), 2-O-trans-caffeoylmangiferin (2), 2-O-trans-coumaroylmangiferin (3), 2-
O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4). The most active compound was 2-O-trans-coumaroylmangiferin
(3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential
antiviral drugs.
Descrição
Palavras-chave
Citação
BRANDÃO, G. C. et al. Antiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) extracts and constituents. Journal of Tropical Medicine, v. 2017, p. 1-11, 2017. Disponível em: <https://www.hindawi.com/journals/jtm/2017/6106959/>. Acesso em: 29 ago. 2017.