Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.

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dc.contributor.authorFerreira, Jaqueline Maria Siqueira
dc.contributor.authorDrumond, Betânia Paiva
dc.contributor.authorGuedes, Maria Isabel Maldonado Coelho
dc.contributor.authorXavier, Marcelo Antônio Pascoal
dc.contributor.authorLeite, Camila Megale Almeida
dc.contributor.authorArantes, Rosa Maria Esteves
dc.contributor.authorMota, Bruno Eduardo Fernandes
dc.contributor.authorAbrahão, Jônatas Santos
dc.contributor.authorAlves, Pedro Augusto
dc.contributor.authorOliveira, Fernando Meireles
dc.contributor.authorFerreira, Paulo César Peregrino
dc.contributor.authorBonjardim, Cláudio Antônio
dc.contributor.authorLobato, Zélia Inês Portela
dc.contributor.authorKroon, Erna Geessien
dc.date.accessioned2014-12-16T23:25:40Z
dc.date.available2014-12-16T23:25:40Z
dc.date.issued2008
dc.description.abstractBrazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact. Some phylogenetic studies have demonstrated the existence of two different populations of Brazilian Vaccinia virus strains circulating in nature, but little is known about their biological characteristics. Therefore, our goal was to study the virulence pattern of seven Brazilian Vaccinia virus strains. Infected BALB/c mice were monitored for morbidity, mortality and viral replication in organs as trachea, lungs, heart, kidneys, liver, brain and spleen. Based on the virulence potential, the Brazilian Vaccinia virus strains were grouped into two groups. One group contained GP1V, VBH, SAV and BAV which caused disease and death in infected mice and the second one included ARAV, GP2V and PSTV which did not cause any clinical signals or death in infected BALB/ c mice. The subdivision of Brazilian Vaccinia virus strains into two groups is in agreement with previous genetic studies. Those data reinforce the existence of different populations circulating in Brazil regarding the genetic and virulence characteristics.pt_BR
dc.identifier.citationFERREIRA, J. M. S. et al. Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains. Plos One, v. 3, p. e3043-e3043, 2008. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003043>. Acesso em: 08 nov. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0003043
dc.identifier.issn1932-6203
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4177
dc.language.isoen_USpt_BR
dc.rights.licenseNenhuma autorização é necessária para depósito dos artigos publicados pelos Periódicos PloS em repositório. Fonte: Plos <http://www.plos.org/open-access/> Acesso em: 14 nov. 2014.pt_BR
dc.subjectVaccinia viruspt_BR
dc.subjectSmallpoxpt_BR
dc.subjectVaríolapt_BR
dc.titleVirulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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