Glutamic acid promotes hair growth in mice.
Nenhuma Miniatura disponível
Data
2021
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in peripheral
tissues. Abnormal distribution of glutamic acid receptors occurs in skin hyperproliferative conditions
such as psoriasis and skin regeneration; however, the biological function of glutamic acid in the
skin remains unclear. Using ex vivo, in vivo and in silico approaches, we showed that exogenous
glutamic acid promotes hair growth and keratinocyte proliferation. Topical application of glutamic
acid decreased the expression of genes related to apoptosis in the skin, whereas glutamic acid
increased cell viability and proliferation in human keratinocyte cultures. In addition, we identifed the
keratinocyte glutamic acid excitotoxic concentration, providing evidence for the existence of a novel
skin signalling pathway mediated by a neurotransmitter that controls keratinocyte and hair follicle
proliferation. Thus, glutamic acid emerges as a component of the peripheral nervous system that
acts to control cell growth in the skin. These results raise the perspective of the pharmacological and
nutritional use of glutamic acid to treat skin diseases.
Descrição
Palavras-chave
Citação
JARA, C. P. et al. Glutamic acid promotes hair growth in mice. Scientifc Reports, v. 11, 2021. Disponível em: <https://www.nature.com/articles/s41598-021-94816-y>. Acesso em: 11 out. 2022.