Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver.
dc.contributor.author | Silva, Maísa | |
dc.contributor.author | Magalhães, Cíntia Lopes de Brito | |
dc.contributor.author | Oliveira, Riva de Paula | |
dc.contributor.author | Silva, Marcelo Eustáquio | |
dc.contributor.author | Pedrosa, Maria Lúcia | |
dc.date.accessioned | 2017-08-11T12:59:54Z | |
dc.date.available | 2017-08-11T12:59:54Z | |
dc.date.issued | 2012 | |
dc.description.abstract | Diabetes mellitus is associated with altered iron homeostasis that can potentially effect reactive oxygen species generation and contribute to diabetes-related complications. We investigated, by quantitative polymerase chain reaction, whether the expression of liver hepcidin, ferritin, and TfR-1 is altered in diabetes. Rats in the control (C) group received a standard diet; control iron (CI) group received a standard diet supplemented with iron; diabetic (D) group received an injection of streptozotocin; and diabetic iron (DI) group received streptozotocin and the diet with iron.Animals of theDgroup showed higher levels of serum iron, increased concentration of carbonyl protein, and a decrease in antioxidant status. Group D rats showed increased hepatic expression of Trf-1 compared to the other groups. Iron supplementation reversed this increase. Hepcidin mRNA was 81% higher in DI than in C and CI rats. The results suggest that diabetes, with or without excess iron, can cause perturbations in iron status, hepcidin and Trf-1 expression. | pt_BR |
dc.identifier.citation | SILVA, M. et al. Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver. Journal of Biochemical and Molecular Toxicology, v. 26, p. 123-129, 2012. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/jbt.20418/epdf>. Acesso em: 20 de jul. 2017. | pt_BR |
dc.identifier.doi | https://doi.org/10.1002/jbt.20418 | |
dc.identifier.issn | 1099-0461 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/8527 | |
dc.identifier.uri2 | http://onlinelibrary.wiley.com/doi/10.1002/jbt.20418/epdf | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Carbonyl iron | pt_BR |
dc.subject | Streptozotocin | pt_BR |
dc.subject | Hepcidin | pt_BR |
dc.subject | Ferritin | pt_BR |
dc.title | Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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