Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity.
dc.contributor.author | Dornas, Waleska Claudia Amaral | |
dc.contributor.author | Lima, Wanderson Geraldo de | |
dc.contributor.author | Santos, Rinaldo Cardoso dos | |
dc.contributor.author | Souza, Melina Oliveira de | |
dc.contributor.author | Silva, Maísa | |
dc.contributor.author | Diniz, Mirla Fiuza | |
dc.contributor.author | Silva, Marcelo Eustáquio | |
dc.date.accessioned | 2015-03-13T13:15:37Z | |
dc.date.available | 2015-03-13T13:15:37Z | |
dc.date.issued | 2012 | |
dc.description.abstract | Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially divided into two groups. Control (CON), which received a normal salt diet and drinking water throughout the study; high fructose (HF), which received a normal salt diet and 20% fructose supplemented drinking water. After 10 weeks, half of the animals from HF group were randomly switched to a high-salt diet and 20% fructose supplemented drinking water (HFS) for more 10 weeks. Serum PON1 activity was determined by synthetic substrate phenyl acetate. HFS rats showed markedly decreased PON1 activity (HFS rats, 44.3 ± 14.4 g/dL versus CON rats, 64.4 ± 13.3 g/dL, P<0.05) as compared to controls. In parallel, the level of oxidative stress, as indicated by thiobarbituric acid reactive substances (TBARS), was increased in HFS rats by 1.2-fold in the liver in relation to controls and was negatively correlated with PON activity. Differential leukocyte counts in blood showed a significant change in lymphocytes and monocytes profile. In conclusion, these results show that PON1 activity is decreased in fructose-fed insulin-resistant rats on a high-salt diet, which may be associated with increased oxidative stress, leading to inflammation. | pt_BR |
dc.identifier.citation | DORNAS, W. C. et al. Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity. Nutrition & Metabolism, v. 9, p. 63, 2012. Disponível em: <http://www.nutritionandmetabolism.com/content/9/1/63>. Acesso em: 08 nov. 2014. | pt_BR |
dc.identifier.doi | https://doi.org/10.1186/1743-7075-9-63 | |
dc.identifier.issn | 1743-7075 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/4626 | |
dc.language.iso | en_US | pt_BR |
dc.rights.license | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo. | pt_BR |
dc.subject | Fructose fed rats | pt_BR |
dc.subject | High salt diet | pt_BR |
dc.subject | Paraoxonase | pt_BR |
dc.subject | Atherosclerosis | pt_BR |
dc.title | Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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