Antibacterial activity of extract and fractions from branches of Protium spruceanum and cytotoxicity on fibroblasts.

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dc.contributor.authorAmparo, Tatiane Roquete
dc.contributor.authorRodrigues, Ivanildes Vasconcelos
dc.contributor.authorSeibert, Janaína Brandão
dc.contributor.authorSouza, Rafaella Hilda Zaniti
dc.contributor.authorOliveira, Amanda Ribeiro de
dc.contributor.authorCabral, Vivette Appolinário Rodrigues
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorBrandão, Geraldo Célio
dc.contributor.authorOkuma, Adriana Akemi
dc.contributor.authorVieira Filho, Sidney Augusto
dc.contributor.authorTeixeira, Luiz Fernando de Medeiros
dc.contributor.authorSouza, Gustavo Henrique Bianco de
dc.date.accessioned2018-05-14T12:42:10Z
dc.date.available2018-05-14T12:42:10Z
dc.date.issued2017
dc.description.abstractThe crude ethanol extract (CEE) and fractions from branches of Protium spruceanum were subjected to antibacterial and cytotoxicity assays. Compounds of the most active fraction were identified by GC-MS and LC-MS. CEE was active against 19 bacteria and the ethyl acetate fraction (EAF) showed the lowest minimum bactericidal concentration (MBC 0.3–80.0 mg/mL). Through time-kill assay was observed that EAF induced rapid bactericidal effect against Staphylococcus saprophyticus. The cytotoxicity tests against L929 fibroblasts showed great potential of EAF on the treatment of infections caused by five bacteria (MBC < IC50). The results provide in vitro scientific support to the possible application of branches of P. spruceanum as antimicrobial agent that may contribute for treatment of infections.pt_BR
dc.identifier.citationAMPARO, T. R. et al. Antibacterial activity of extract and fractions from branches of Protium spruceanum and cytotoxicity on fibroblasts. Natural Product Research, v. 01, p. 1-5, 2017. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1354182?journalCode=gnpl20>. Acesso em: 05 abr. 2018.pt_BR
dc.identifier.issn14786427
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/9928
dc.identifier.uri2https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1354182?journalCode=gnpl20pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectProtium spruceanumpt_BR
dc.subjectCytotoxicitypt_BR
dc.subjectAntbacterial activitypt_BR
dc.titleAntibacterial activity of extract and fractions from branches of Protium spruceanum and cytotoxicity on fibroblasts.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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