Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro.
dc.contributor.author | Silva, Marlene Lourenço da | |
dc.contributor.author | Stehmann, João Renato | |
dc.contributor.author | Serafim, Mateus Sá Magalhães | |
dc.contributor.author | Vale, Valdicley Vieira | |
dc.contributor.author | Gontijo, Douglas da Costa | |
dc.contributor.author | Brandão, Geraldo Célio | |
dc.contributor.author | Kroon, Erna Geessien | |
dc.contributor.author | Oliveira, Alaíde Braga de | |
dc.date.accessioned | 2020-05-22T15:34:13Z | |
dc.date.available | 2020-05-22T15:34:13Z | |
dc.date.issued | 2019 | |
dc.description.abstract | The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97). | pt_BR |
dc.identifier.citation | SILVA, M. L. et al. Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro. Natural Product Research, nov. 2019. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1690487>. Acesso em: 10 fev. 2020. | pt_BR |
dc.identifier.doi | https://doi.org/10.1080/14786419.2019.1690487 | pt_BR |
dc.identifier.issn | 1478-6427 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/12239 | |
dc.identifier.uri2 | https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1690487 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Yellow fever virus | pt_BR |
dc.subject | Plumieride | pt_BR |
dc.subject | Spectroscopic analyses | pt_BR |
dc.title | Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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