Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro.

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dc.contributor.authorSilva, Marlene Lourenço da
dc.contributor.authorStehmann, João Renato
dc.contributor.authorSerafim, Mateus Sá Magalhães
dc.contributor.authorVale, Valdicley Vieira
dc.contributor.authorGontijo, Douglas da Costa
dc.contributor.authorBrandão, Geraldo Célio
dc.contributor.authorKroon, Erna Geessien
dc.contributor.authorOliveira, Alaíde Braga de
dc.date.accessioned2020-05-22T15:34:13Z
dc.date.available2020-05-22T15:34:13Z
dc.date.issued2019
dc.description.abstractThe hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97).pt_BR
dc.identifier.citationSILVA, M. L. et al. Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro. Natural Product Research, nov. 2019. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1690487>. Acesso em: 10 fev. 2020.pt_BR
dc.identifier.doihttps://doi.org/10.1080/14786419.2019.1690487pt_BR
dc.identifier.issn1478-6427
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/12239
dc.identifier.uri2https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1690487pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectYellow fever viruspt_BR
dc.subjectPlumieridept_BR
dc.subjectSpectroscopic analysespt_BR
dc.titleHimatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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