Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers : probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres.
dc.contributor.author | Lana, Gwenaelle Elza Nathalie Pound | |
dc.contributor.author | Garcia, Giani Martins | |
dc.contributor.author | Trindade, Izabel Cristina | |
dc.contributor.author | Oliveira, Patricia Capelari de | |
dc.contributor.author | Pontífice, Thaís Godinho | |
dc.contributor.author | Vilela, José Mário Carneiro | |
dc.contributor.author | Andrade, Margareth Spangler | |
dc.contributor.author | Nottelet, Benjamin | |
dc.contributor.author | Postacchini, Bruna Bueno | |
dc.contributor.author | Mosqueira, Vanessa Carla Furtado | |
dc.date.accessioned | 2019-04-22T12:37:35Z | |
dc.date.available | 2019-04-22T12:37:35Z | |
dc.date.issued | 2019 | |
dc.description.abstract | For best photosensitizer activity phthalocyanine dyes used in photodynamic therapy should be molecularly dispersed. Polyethylene glycol-block-polylactide derivatives presenting benzyl side-groups were synthesized to encapsulate a highly lipophilic phthalocyanine dye (AlClPc) and evaluate the effect of π-π interactions on the nanocarrier colloidal stability and dye dispersion. Copolymers with 0, 1, 2 and 6 mol% of benzyl glycidyl ether (BGE) were obtained via polyethylene glycol initiated ring-opening copolymerization of D,L-lactide with BGE. The block copolymers formed stable, monodisperse nanospheres with low in vitro cytotoxicity. AlClPc loading increased the nanosphere size and affected their colloidal stability. The photo-physical properties of the encapsulated dye, studied in batch and after separation by field flow fractionation, demonstrated the superiority of plain PEG-PLA over BGE-containing copolymers in maintaining the dye in its monomeric (non-aggregated) form in aqueous suspension. High dye encapsulation and sustained dye release suggest that these nanocarriers are good candidates for photodynamic therapy. | pt_BR |
dc.identifier.citation | LANA, G. N. E. P. et al. Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers : probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres. Materials Science and Engineering: C, v. 94, p. 220-233, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0928493118307690>. Acesso em: 7 mar. 2019. | pt_BR |
dc.identifier.issn | 0928-4931 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/11080 | |
dc.identifier.uri2 | https://www.sciencedirect.com/science/article/pii/S0928493118307690 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Drug nanocarrier | pt_BR |
dc.subject | Biodegradable polymer | pt_BR |
dc.subject | Amphiphilic block copolym | pt_BR |
dc.subject | Field flow fractionation | pt_BR |
dc.title | Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers : probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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