Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz.
dc.contributor.author | Moraes, Sabrina Zelice da Cruz de | |
dc.contributor.author | Shan, Andrea Yu Kwan Villar | |
dc.contributor.author | Melo, Marlange Almeida Oliveira | |
dc.contributor.author | Silva, Juliane Pereira da | |
dc.contributor.author | Passos, Fabiolla Rocha Santos | |
dc.contributor.author | Graça, Ariel de Souza | |
dc.contributor.author | Araújo, Brancilene Santos de | |
dc.contributor.author | Quintans, Jullyana de Souza Siqueira | |
dc.contributor.author | Quintans Júnior, Lucindo José | |
dc.contributor.author | Barreto, Emiliano de Oliveira | |
dc.contributor.author | Brandão, Geraldo Célio | |
dc.contributor.author | Estevam, Charles dos Santos | |
dc.date.accessioned | 2021-12-06T20:09:51Z | |
dc.date.available | 2021-12-06T20:09:51Z | |
dc.date.issued | 2020 | pt_BR |
dc.description.abstract | Ethnopharmacology relevance: Poncianella pyramidalis (Leguminosae) is a Caatinga plant used in folk medicine because of its pharmacological properties, which include anti-inflammatory action. However, chemical compounds re sponsible for this effect have not yet been identified. Aim of the study: This study aimed to evaluate the antioxidant, antinociceptive and anti-inflammatory effects of the ethyl acetate fraction from the inner bark of P. pyramidalis. Material and methods: Total phenol content (TP) was estimated using the Folin-Ciocalteu reagent, while in vitro antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Chemical identification was done using LC-PDA/MS and LC-ESI/MS/MS. In vivo antinociceptive and anti-in flammatory properties were investigated using formalin, mechanical hypernociception and carrageenan-induced pleurisy assays in mice. Results: TP was 525.08 ± 17.49 μg mg−1 gallic acid equivalent. The ethyl acetate fraction (EAF) inhibited 87.76% of the DPPH radical with an EC50 of 22.94 μg mL−1 and Antioxidant Activity Index of 1.74. LC-PDA/MS and LC-ESI/MS/MS identified 15 compounds that are mostly derived from gallic and ellagic acids. Regarding in vivo antinociceptive and anti-inflammatory activity, EAF (100 mg kg-1) significantly reduced the nociceptive response in the second phase of the formalin assay by 50% (p < 0.01) compared with the control group. In the hypernociception test, a significant (p < 0.001) anti-hyperalgesic effect of EAF (100 mg kg-1) was observed up to the third hour of evaluation (p < 0.001). In the carrageenan assay, EAF (100 mg kg-1) was shown to inhibit protein extravasation, increase total leukocytes and neutrophils, and inhibit mononuclear cells. Conclusion: These results demonstrate EAF from the inner bark of P. pyramidalis has strong in vitro antioxidant effect as well as in vivo antinociceptive and anti-inflammatory activities, which may be attributed to the bark being rich in phenolic compounds derived from gallic acid. | pt_BR |
dc.identifier.citation | MORAES, S. Z. da C. de et al. Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz. Journal of Ethnopharmacology, p. 112563, 2020. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0378874119319257?via%3Dihub>. Acesso em: 10 jun. 2021. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.jep.2020.112563 | pt_BR |
dc.identifier.issn | 0378-8741 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/14096 | |
dc.identifier.uri2 | https://www.sciencedirect.com/science/article/abs/pii/S0378874119319257?via%3Dihub | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Phenolic | pt_BR |
dc.subject | Carrageenan | pt_BR |
dc.subject | Hyperalgesic | pt_BR |
dc.subject | Hypernociception | pt_BR |
dc.title | Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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