Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/986
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dc.contributor.authorAraújo, Márcio Sobreira Silva-
dc.contributor.authorAndrade, Renata Aline de-
dc.contributor.authorVianna, Leonardo Rocha-
dc.contributor.authorMayrink, Wilson-
dc.contributor.authorReis, Alexandre Barbosa-
dc.contributor.authorAvelar, Renato Sathler-
dc.contributor.authorCarvalho, Andréa Teixeira de-
dc.contributor.authorAndrade, Mariléia Chaves-
dc.contributor.authorMelo, Maria Norma-
dc.contributor.authorMartins Filho, Olindo Assis-
dc.date.accessioned2012-07-05T14:43:12Z-
dc.date.available2012-07-05T14:43:12Z-
dc.date.issued2008-
dc.identifier.citationARAÚJO, M. S. S. et al. Despite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis. Vaccine, v. 26, n.18, p. 2211-2224, abr. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0264410X08002351>. Acesso em: 05 jul. 2012.pt_BR
dc.identifier.issn0264410X-
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/986-
dc.description.abstractPhenotypic features of peripheral blood leukocytes have been investigated as a prerequisite to characterize the protective immunity attributed to both Leishvaccine and Leishmune ® . Our results showed that either those vaccine were accompanied by distinct profiles on innate immune compartment. While Leishvaccine promoted early changes in phenotypic fea-tures of neutrophils and eosinophils with late involvement of monocytes, Leishmune ® induced early and persistent activation of neutrophils and monocytes, without changes on eosinophil activation status. Regarding the adaptive immunity, Leishvaccine sponsored a mixed profile, associated with phenotypic changes of T and B-lymphocytes. Major phenotypic changes in CD4 + T-cells with transient activation of CD8 + T-cell, besides decreased frequency of B-cell expressingpt_BR
dc.language.isoen_USpt_BR
dc.subjectCanine visceral leishmaniasispt_BR
dc.subjectLeishvaccinept_BR
dc.subjectLeishmunept_BR
dc.subjectLymphocyte phenotypespt_BR
dc.titleDespite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291401473802.-
Appears in Collections:DEACL - Artigos publicados em periódicos

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