Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/971
Title: Histological study of cell migration in the dermis of hamsters after immunisation with two different vaccines against visceral leishmaniasis.
Authors: Moreira, Nádia das Dores
Giunchetti, Rodolfo Cordeiro
Carneiro, Cláudia Martins
Souza, Juliana Vitoriano de
Roatt, Bruno Mendes
Malaquias, Luiz Cosme Cotta
Oliveira, Rodrigo Corrêa de
Reis, Alexandre Barbosa
Keywords: Histopathology
Inflammation and cell migration
Hamster
Leishmania - vaccines antingens
Saponin adjuvant
Issue Date: 2009
Citation: MOREIRA, N. das. D. et al. Histological study of cell migration in the dermis of hamsters after immunisation with two different vaccines against visceral leishmaniasis. Veterinary Immunology and Immunopathology, v. 128, n. 4, p. 418-424, 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0165242708007708>. Acesso em: 04 jul. 2012.
Abstract: Vaccine candidates, including live and/or killed parasites, Leishmania -purified fractions, defined recombinant antigens and antigen-encoding DNA-plasmids have been proposed to use as vaccine anti- Leishmania . More recently, the hamsters have been used to pre selection of antigens candidate to apply in further experiments using canine model. In this report we evaluated the kinetics of cell migration in dermal inflammatory infiltrate, circulating leukocytes and the presence of nitric oxide (NO)/induced nitric oxide synthase during the early (1–24 h) and late (48–168 h) periods following inoculation of hamsters with antigenic components of anti-canine visceral leishmaniasis vaccines Leishmune 1 and Leishmania braziliensis antigen (LB) with and without saponin (Sap) adjuvant. Our results show that LB caused an early reduction of lymphocytes in the dermis while Sap and LBSap triggered a late recruitment, suggesting the role of the adjuvant in the traffic of antigen-presenting cells and the induction of lymphocyte migration. In that manner our results suggest that the kinetics of cell migration on hamster model may be of value in the selection of vaccine antigens prior the tests in dogs particularly in respect of the toxicity of the preparations.
URI: http://www.repositorio.ufop.br/handle/123456789/971
ISSN: 01652427
metadata.dc.rights.license: O periódico Veterinary Immunology and Immunopathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281420495198.
Appears in Collections:DEACL - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_HistologicalStudyCell.pdf1,17 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.