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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Oliveira, Katia Mara de | - |
dc.contributor.author | Correa, Rodrigo de Souza | - |
dc.contributor.author | Barbosa, Marília Imaculada Frazão | - |
dc.contributor.author | Ellena, Javier Alcides | - |
dc.contributor.author | Cominetti, Márcia Regina | - |
dc.contributor.author | Batista, Alzir Azevedo | - |
dc.date.accessioned | 2018-03-14T13:16:04Z | - |
dc.date.available | 2018-03-14T13:16:04Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | OLIVEIRA, K. M. de et al. Ruthenium(II)/triphenylphosphine complexes: an effective way to improve the cytotoxicity of lapachol. Polyhedron, v. 130, p. 108-114, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0277538717302723>. Acesso em: 15 set. 2017. | pt_BR |
dc.identifier.issn | 0277-5387 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/9631 | - |
dc.description.abstract | This study reports on the synthesis of a new ruthenium(II) complex, cis-[Ru(PPh3)2(lap)2] (1) with two molecules of the natural product known as lapachol [lap = (2-hydroxy-3-(3-methyl-2-buthenyl)-1,4- naphthoquinone)] coordinated as bidentated by oxygen atoms and two monodentate PPh3 (triphenylphosphine) in a cis configuration. This neutral complex was characterized by spectroscopic analysis, single-crystal X-ray diffraction, elemental analysis, molar conductivity and cyclic voltammetry. In this study, ruthenium complex trans-[Ru(lap)(PPh3)2(phen)]PF6 (2) was used for comparison purposes. The interaction of ruthenium complexes (1) and (2) with CT-DNA was evaluated by UV–Vis and circular dichroism and it was observed that the complexes interact weakly with the CT-DNA. The fluorescence measurements suggest that complex (1) shows stronger interaction with HSA and BSA proteins compared to complex (2). Cytotoxicity assays against A549 (lung cancer), MDA-MB-231 (breast cancer) and V79 (non-tumoral lung) revealed that complex (2) is more active (lower IC50 values) than complex (1) and the cisplatin, used as a reference. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Ruthenium complexes | pt_BR |
dc.subject | Lapachol | pt_BR |
dc.subject | Albumin binding | pt_BR |
dc.subject | Cytotoxicity | pt_BR |
dc.title | Ruthenium(II)/triphenylphosphine complexes : an effective way to improve the cytotoxicity of lapachol. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.identifier.uri2 | http://www.sciencedirect.com/science/article/pii/S0277538717302723 | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.poly.2017.04.005 | - |
Aparece nas coleções: | DEQUI - Artigos publicados em periódicos |
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ARTIGO_RutheniumTriphenylphosphine.pdf Restricted Access | 832,63 kB | Adobe PDF | Visualizar/Abrir |
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