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http://www.repositorio.ufop.br/jspui/handle/123456789/9631
Title: | Ruthenium(II)/triphenylphosphine complexes : an effective way to improve the cytotoxicity of lapachol. |
Authors: | Oliveira, Katia Mara de Correa, Rodrigo de Souza Barbosa, Marília Imaculada Frazão Ellena, Javier Alcides Cominetti, Márcia Regina Batista, Alzir Azevedo |
Keywords: | Ruthenium complexes Lapachol Albumin binding Cytotoxicity |
Issue Date: | 2017 |
Citation: | OLIVEIRA, K. M. de et al. Ruthenium(II)/triphenylphosphine complexes: an effective way to improve the cytotoxicity of lapachol. Polyhedron, v. 130, p. 108-114, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0277538717302723>. Acesso em: 15 set. 2017. |
Abstract: | This study reports on the synthesis of a new ruthenium(II) complex, cis-[Ru(PPh3)2(lap)2] (1) with two molecules of the natural product known as lapachol [lap = (2-hydroxy-3-(3-methyl-2-buthenyl)-1,4- naphthoquinone)] coordinated as bidentated by oxygen atoms and two monodentate PPh3 (triphenylphosphine) in a cis configuration. This neutral complex was characterized by spectroscopic analysis, single-crystal X-ray diffraction, elemental analysis, molar conductivity and cyclic voltammetry. In this study, ruthenium complex trans-[Ru(lap)(PPh3)2(phen)]PF6 (2) was used for comparison purposes. The interaction of ruthenium complexes (1) and (2) with CT-DNA was evaluated by UV–Vis and circular dichroism and it was observed that the complexes interact weakly with the CT-DNA. The fluorescence measurements suggest that complex (1) shows stronger interaction with HSA and BSA proteins compared to complex (2). Cytotoxicity assays against A549 (lung cancer), MDA-MB-231 (breast cancer) and V79 (non-tumoral lung) revealed that complex (2) is more active (lower IC50 values) than complex (1) and the cisplatin, used as a reference. |
URI: | http://www.repositorio.ufop.br/handle/123456789/9631 |
metadata.dc.identifier.uri2: | http://www.sciencedirect.com/science/article/pii/S0277538717302723 |
metadata.dc.identifier.doi: | https://doi.org/10.1016/j.poly.2017.04.005 |
ISSN: | 0277-5387 |
Appears in Collections: | DEQUI - Artigos publicados em periódicos |
Files in This Item:
File | Description | Size | Format | |
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ARTIGO_RutheniumTriphenylphosphine.pdf Restricted Access | 832,63 kB | Adobe PDF | View/Open |
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