Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/9631
Title: Ruthenium(II)/triphenylphosphine complexes : an effective way to improve the cytotoxicity of lapachol.
Authors: Oliveira, Katia Mara de
Correa, Rodrigo de Souza
Barbosa, Marília Imaculada Frazão
Ellena, Javier Alcides
Cominetti, Márcia Regina
Batista, Alzir Azevedo
Keywords: Ruthenium complexes
Lapachol
Albumin binding
Cytotoxicity
Issue Date: 2017
Citation: OLIVEIRA, K. M. de et al. Ruthenium(II)/triphenylphosphine complexes: an effective way to improve the cytotoxicity of lapachol. Polyhedron, v. 130, p. 108-114, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0277538717302723>. Acesso em: 15 set. 2017.
Abstract: This study reports on the synthesis of a new ruthenium(II) complex, cis-[Ru(PPh3)2(lap)2] (1) with two molecules of the natural product known as lapachol [lap = (2-hydroxy-3-(3-methyl-2-buthenyl)-1,4- naphthoquinone)] coordinated as bidentated by oxygen atoms and two monodentate PPh3 (triphenylphosphine) in a cis configuration. This neutral complex was characterized by spectroscopic analysis, single-crystal X-ray diffraction, elemental analysis, molar conductivity and cyclic voltammetry. In this study, ruthenium complex trans-[Ru(lap)(PPh3)2(phen)]PF6 (2) was used for comparison purposes. The interaction of ruthenium complexes (1) and (2) with CT-DNA was evaluated by UV–Vis and circular dichroism and it was observed that the complexes interact weakly with the CT-DNA. The fluorescence measurements suggest that complex (1) shows stronger interaction with HSA and BSA proteins compared to complex (2). Cytotoxicity assays against A549 (lung cancer), MDA-MB-231 (breast cancer) and V79 (non-tumoral lung) revealed that complex (2) is more active (lower IC50 values) than complex (1) and the cisplatin, used as a reference.
URI: http://www.repositorio.ufop.br/handle/123456789/9631
metadata.dc.identifier.uri2: http://www.sciencedirect.com/science/article/pii/S0277538717302723
metadata.dc.identifier.doi: https://doi.org/10.1016/j.poly.2017.04.005
ISSN: 0277-5387
Appears in Collections:DEQUI - Artigos publicados em periódicos

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