Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/9628
Title: Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
Authors: Santos, Edjane Rocha dos
Correa, Rodrigo de Souza
Cunha, Lucas Vinícius Pozzi da
Graminha, Angelica Ellen
Araujo, Heloisa Sobreiro Selistre de
Pavan, Fernando Rogério
Batista, Alzir Azevedo
Keywords: Ruthenium complexes
Cytotoxicity
Diastereoisomers
Amino acid
Issue Date: 2017
Citation: SANTOS, E. R. dos et al. Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Inorganica Chimica Acta, v. 463, p. 1-6, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0020169317304681>. Acesso em: 15 set. 2017.
Abstract: Six new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,20-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,20-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol.
URI: http://www.repositorio.ufop.br/handle/123456789/9628
ISSN: 00201693
metadata.dc.rights.license: O periódico Inorganica Chimica Acta concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4211380089785.
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