Please use this identifier to cite or link to this item:
Title: Influence of clinical status and parasite load on Erythropoiesis and Leucopoiesis in dogs naturally infected with Leishmania (Leishmania) chagasi.
Authors: Abreu, Raquel Trópia de
Carvalho, Maria das Graças
Carneiro, Cláudia Martins
Giunchetti, Rodolfo Cordeiro
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Vital, Wendel Coura
Oliveira, Rodrigo Corrêa de
Reis, Alexandre Barbosa
Issue Date: 2011
Citation: ABREU, R. T. de et al. Influence of clinical status and parasite load on Erythropoiesis and Leucopoiesis in dogs naturally infected with Leishmania (Leishmania) chagasi. Plos One, v. 6, n. 5, 2011. Disponível em: <>. Acesso em: 04 jul. 2012.
Abstract: Background: The bone marrow is considered to be an important storage of parasites in Leishmania -infected dogs, although little is known about cellular genesis in this organ during canine visceral leishmaniasis (CVL). Methodology/Principal Findings:The aim of the present study was to evaluate changes in erythropoiesis and leucopoiesis in bone marrow aspirates from dogs naturally infected with Leishmania chagasi and presenting different clinical statuses and bone marrow parasite densities. The evolution of CVL from asymptomatic to symptomatic status was accompanied by increasing parasite density in the bone marrow. The impact of bone marrow parasite density on cellularity was similar in dogs at different clinical stages, with animals in the high parasite density group. Erythroid and eosinophilic hypoplasia, proliferation of neutrophilic precursor cells and significant increases in lymphocytes and plasma cell numbers were the major alterations observed. Differential bone marrow cell counts revealed increases in the myeloid:erythroid ratio associated to increased numbers of granulopoietic cells in the different clinical groups compared with non-infected dogs. Conclusions: Analysis of the data obtained indicated that the assessment of bone marrow constitutes an additional and useful tool by which to elaborate a prognosis for CVL.
ISSN: 19326203
metadata.dc.rights.license: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: o próprio artigo.
Appears in Collections:DEACL - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_InfluenceClinicalStatus.pdf628,13 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.