Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/954
Title: Immunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis.
Authors: Araújo, Márcio Sobreira Silva
Andrade, Renata Aline de
Avelar, Renato Sathler
Magalhães, Camila Paula
Carvalho, Andréa Teixeira de
Andrade, Mariléia Chaves
Campolina, Sabrina Sidney
Melo, Maria Norma
Vianna, Leonardo Rocha
Mayrink, Wilson
Reis, Alexandre Barbosa
Malaquias, Luiz Cosme Cotta
Rocha, Luciana Morais
Martins Filho, Olindo Assis
Issue Date: 2011
Citation: ARAÚJO, M. S. S. et al. Immunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis. Veterinary Immunology and Immunopathology, v. 141, n. 1-2, p. 64-75, 2011. Disponível em: <https://www.sciencedirect.com/science/article/pii/S016524271100050X>. Acesso em: 04 jul. 2012.
Abstract: In this study, we summarized the major phenotypic/functional aspects of circulating leuko-cytes following canine immunization with Leishvaccine and Leishmune ®. Our findings showed that Leishvaccine triggered early changes in the innate immunity (neutrophils and eosinophils) with late alterations on monocytes. Conversely, Leishmune ® induced early phenotypic changes in both, neutrophils and monocytes. Moreover, Leishvaccine triggered mixed activation-related phenotypic changes on T-cells (CD4 + and CD8 +) and B-lymphocytes, hereas Leishmune® promoted a selective response, mainly associated with CD8 + T-cell activation. Mixed cytokine profile (IFN- /IL-4) was observed in Leishvaccine immunized dogs whereas a selective pro-inflammatory pattern (IFN- /NO) was induced by Leishmune ® vaccination. The distinct immunological profile triggered by Leishvaccine and Leishmune ® may be a direct consequence of the distinct biochemical composition of these immunobiological, i.e. complex versus purified Leishmaniaantigen along with Bacillus Calmette-Guérin (BCG) versus saponin adjuvant. Both immunobiologicals are able to acti-vate phagocytes and CD8 + T-cells and therefore could be considered as a putative vaccines against canine visceral leishmaniasis (CVL)
URI: http://www.repositorio.ufop.br/handle/123456789/954
ISSN: 01652427
metadata.dc.rights.license: O periódico Veterinary Immunology and Immunopathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3287141001258.
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