Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/9459
Title: Structural and physical–chemical evaluation of bradykinin potentiating peptide and its high soluble supramolecular complex.
Authors: Sousa, Frederico Barros de
Denadai, Ângelo Márcio Leite
Lula, Ivana Silva
Ianzer, Danielle Alves
Malaspina, Érica Resende
Camargo, Antônio Carlos Martins de
Santos, Robson Augusto Souza dos
Sinisterra, Ruben Dario
Keywords: Peptides
Bradykinin potentiating peptides
Supramolecular complexes
Intermolecular interactions
Issue Date: 2010
Citation: SOUSA, F. B. de et al. Structural and physical–chemical evaluation of bradykinin potentiating peptide and its high soluble supramolecular complex. Journal Of Inclusion Phenomena And Macrocyclic Chemistry, v. 67, p. 407-422, 2010. Disponível em: <https://link.springer.com/article/10.1007/s10847-009-9723-6>. Acesso em: 16 jan. 2018.
Abstract: The supramolecular interactions between a Bradykinin Potentiating Peptide (BPP10c) and b-cyclodextrin (bCD) have been investigated by using several techniques. These new properties acquired by the inclusion phenomena are important in developing a strategy for pharmaceutical formulation. The BPP10c structural elucidation and its inclusion complex formed have been investigated using Nuclear Magnetic Resonance techniques. The peptide secondary structure was investigated using infrared spectroscopy in solution, Circular Dichroism and NMR. In addition, the thermodynamic parameters of the inclusion process were also evaluated using Isothermal Titration Calorimetry. The results obtained by these physical– chemical techniques suggested a 1:1 complex formed by interaction between the Tryptophan amino acid residue and the bCD cavity. The peptide secondary structure was not substantially modified for the inclusion process. In addition, the inclusion process proved to be spontaneous (DG8 = -2.53 kcal mol-1), with an enthalpy reduction (DH8 = -3.72 kcal mol-1) and a favored entropic variation (TDS8 = -1.19 kcal mol-1).
URI: http://www.repositorio.ufop.br/handle/123456789/9459
metadata.dc.identifier.uri2: https://link.springer.com/article/10.1007/s10847-009-9723-6
ISSN: 15731111
Appears in Collections:DEMAT - Artigos publicados em periódicos

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