Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/9187
Title: Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats.
Authors: Custódio, Carlos Henrique Xavier
Miranda, José Rodolfo Rubini
Yamaguchi, Juliana
Silveira, Kátia Daniela da
Teixeira, Mauro Martins
Chianca Júnior, Deoclécio Alves
Silva, Ana Cristina Simões e
Santos, Robson Augusto Souza dos
Camargo, Antônio Carlos Martins de
Ianzer, Danielle Alves
Keywords: Blood pressure
Heart rate
Hypertension
Prolinerich oligopeptides
Renal function
Issue Date: 2017
Citation: XAVIER, C. H. et al. Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats. International Journal Of Peptide Research And Therapeutics, v. 25, p. 1-5, 2017. Disponível em: <https://goo.gl/CkVXEB>. Acesso em: 15 set. 2017.
Abstract: Proline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/ kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1– 43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj- PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Δ = −13 to −24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal functi
URI: http://www.repositorio.ufop.br/handle/123456789/9187
metadata.dc.identifier.uri2: https://goo.gl/CkVXEB
ISSN: 15733904 
Appears in Collections:DECBI - Artigos publicados em periódicos

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