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Title: The exposure to formaldehyde causes renal dysfunction, inflammation and redox imbalance in rats.
Authors: Ramos, Camila de Oliveira
Nardeli, Clarissa Rodrigues
Campos, Keila Karine Duarte
Pena, Karina Braga
Machado, Dafne Fernandes
Bandeira, Ana Carla Balthar
Costa, Guilherme de Paula
Silva, André Talvani Pedrosa da
Bezerra, Frank Silva
Keywords: Renal tissue
Issue Date: 2017
Citation: RAMOS, C. O. et al. The exposure to formaldehyde causes renal dysfunction, inflammation and redox imbalance in rats. Experimental And Toxicologic Pathology, v. 69, p. 367-372, 2017. Disponível em: <>. Acesso em: 15 set. 2017.
Abstract: Twenty-eight Fischer male rats were divided into four groups: control group (CG), exposed to the ambient air, and groups exposed to formaldehyde (FA) at concentrations of 1% (FA1%), 5% (FA5%) and 10% (FA10%). Kidney function was assessed by dosage of uric acid, creatinine and urea. Morphometry was performed on the thickness of the lumen of Bowman's capsule and diameter of the lumen of the renal tubules. We evaluated the redox imbalance through the catalase and superoxide dismutase activity as well as oxidative damage by lipid peroxidation. Inflammatory chemokines CCL2, CCL3 and CCL5 were analyzed by enzyme immunoassays. There was an increase in the concentration of urea in FA10% compared with CG and FA1%. The levels of creatinine, renal lumen and lipid peroxidation increased in all FA-treated groups compared with CG. The concentration of uric acid in FA10% was lower compared with all other groups. There was an increase in the space of Bowman's capsule in FA5% and FA10% compared with CG and FA1%. However, the superoxide dismutase activity was higher in FA5% compared with other groups while CCL5 was higher in FA1% compared with CG. The exposure to formaldehyde in a short period of time leads to changes in the kidney function, inflammation and morphology, as well as promoted the increase of superoxide dismutase activity and oxidative damage.
ISSN: 09402993
metadata.dc.rights.license: O periódico Experimental and Toxicologic Pathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4210820750568.
Appears in Collections:DECBI - Artigos publicados em periódicos

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