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Title: Expression and production of cardiac angiogenic mediators depend on the Trypanosoma cruzi-genetic population in experimental C57BL/6 mice infection.
Authors: Bajracharya, Deena Shrestha
Bajracharya, Bijay
Costa, Guilherme de Paula
Salles, Beatriz Cristina Silveira
Leite, Ana Luísa Junqueira
Menezes, Ana Paula de Jesus
Souza, Débora Maria Soares de
Oliveira, Laser Antônio Machado de
Silva, André Talvani Pedrosa da
Keywords: Inflammation
Issue Date: 2017
Citation: BAJRACHARYA, D. S. et al. Expression and production of cardiac angiogenic mediators depend on the Trypanosoma cruzi-genetic population in experimental C57BL/6 mice infection. Microvascular Research, v. 110, p. 56-63, 2017. Disponível em: <>. Acesso em: 15 set. 2017.
Abstract: Mammalian cardiac cells are important targets to the protozoan Trypanosoma cruzi. The inflammatory reaction in the host aims at eliminating this parasite, can lead to cell destruction, fibrosis and hypoxia. Local hypoxia iswelldefined stimulus to the production of angiogenesis mediators. Assuming that different genetic T. cruzi populations induce distinct inflammation and disease patterns, the current study aims to investigate whether the production of inflammatory and angiogenic mediators is a parasite strain-dependent condition. C57BL/6 mice were infectedwith the Y and Colombian strains of T. cruzi and euthanized at the 12th and 32nd days, respectively. The blood and heart tissue were processed in immune assays and/or qPCR (TNF, IL-17, IL-10, CCL2, CCL3, CCL5, CCR2, CCR5 and angiogenic factors VEGF, Ang-1, Ang-2) and in histological assays. The T. cruzi increased the inflammatory and angiogenicmediators in the infectedmicewhen theywere compared to non-infected animals.However, the Colombian strain has led to higher (i) leukocyte infiltration, (ii) cardiac TNF and CCL5 production/expression, (iii) cardiac tissue parasitism, and to higher (iv) ratio between heart/body weights. On the other hand, the Colombian strain has caused lower production and expression VEGF, Ang-1 and Ang-2, when it was compared to the Y strain of the parasite. The present study highlights that the T. cruzi-genetic population defines the pattern of angiogenic/inflammatory mediators in the heart tissue, and that itmay contribute to themagnitude of the cardiac pathogenesis. Besides, such assumption opens windows to the understanding of the angiogenic mediator's role in association with the experimental T. cruzi infection.
ISSN: 00262862
metadata.dc.rights.license: O periódico Microvascular Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4210821360555.
Appears in Collections:DECBI - Artigos publicados em periódicos

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