Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/9161
Title: Nonsteroidal anti-inflammatory is more effective than anti-oxidant therapy in counteracting oxidative/nitrosative stress and heart disease in T. cruzi-infected mice.
Authors: Novaes, Rômulo Dias
Santos, Eliziária Cardoso dos
Fialho, Maria do Carmo Queiroz
Gonçalves, Wagner Gonzaga
Sequetto, Priscila Lima
Silva, André Talvani Pedrosa da
Gonçalves, Reggiani Vilela
Keywords: Cardiovascular pathology
Experimental therapeutics
Issue Date: 2017
Citation: NOVAES, R. D. et al. Nonsteroidal anti-inflammatory is more effective than anti-oxidant therapy in counteracting oxidative/nitrosative stress and heart disease in T. cruzi-infected mice. Parasitology , v. 30, p. 1-13, 2017. Disponível em: <https://www.cambridge.org/core/journals/parasitology/article/nonsteroidal-antiinflammatory-is-more-effective-than-antioxidant-therapy-in-counteracting-oxidativenitrosative-stress-and-heart-disease-in-t-cruziinfected-mice/804355CC52A2B8E85A0CC7CA315F7D4E>. Acesso em: 15 set. 2017.
Abstract: We compared the relevance of ibuprofen, vitamins C and E to control oxidative/nitrosative stress and heart disease in mice infected by Trypanosoma cruzi. Swiss mice were randomized into five groups: control, uninfected; infected without treatment; and infected treated with vitamins C, E or ibuprofen. Animals were inoculated with 2000 trypomastigote forms of T. cruzi. After 20 days, infected mice presented reduced vitamin C and E tissue levels, high cytokines (interferon gamma, tumour necrosis factor-α, interleukin 10 and chemokine ligand 2), prostaglandin F2α (PGF2α) and nitric oxide (NO) cardiac production, intense myocarditis and reactive tissue damage, which was directly correlated with the intensity of the inflammatory infiltrate and the degree of pathological cardiac remodelling. Vitamins C and E supplementation were irrelevant to counteract reactive tissue damage and myocarditis in infected animals. Conversely, ibuprofen reduced tissue levels of cytokines, PGF2α and NO, as well as lipid and protein oxidation, antioxidant enzyme activity and the cardiac damage, without interfering with heart parasitism. Our results do not support the applicability of vitamin C and E supplementation in the management of acute Chagas cardiomyopathy. By controlling the inflammatory infiltrate, anti-inflammatory-based therapy proved to be a more rational strategy than a direct antioxidant therapy in attenuating oxidative/nitrosative stress and cardiac damage.
URI: http://www.repositorio.ufop.br/handle/123456789/9161
metadata.dc.identifier.uri2: https://www.cambridge.org/core/journals/parasitology/article/nonsteroidal-antiinflammatory-is-more-effective-than-antioxidant-therapy-in-counteracting-oxidativenitrosative-stress-and-heart-disease-in-t-cruziinfected-mice/804355CC52A2B8E85A0CC7CA315F7D4E
metadata.dc.identifier.doi: https://doi.org/10.1017/S0031182016002675
ISSN: 1469-8161
Appears in Collections:DECBI - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_NonsteroidalAntiInflammatory.pdf1,03 MBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.