Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/9035
Title: Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.
Authors: Carraro, Júlia Cristina Cardoso
Hermsdorff, Helen Hermana Miranda
Mansego, Maria Luisa
Zulet, Maria Angeles
Milagro, Fermín Ignacio
Bressan, Josefina
Martínez, J. Alfredo
Keywords: Biomarker
Inflammation
Epigenetics
DNA methylation
Diet
Issue Date: 2016
Citation: CARRARO, J. C. C. et al. Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. Journal of Nutrigenetics and Nutrigenomics, v. 9, p. 95-105, 2016. Disponível em: <https://www.karger.com/Article/Abstract/448101>. Acesso em: 29 ago. 2017.
Abstract: Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation.
URI: http://www.repositorio.ufop.br/handle/123456789/9035
metadata.dc.identifier.uri2: https://www.karger.com/Article/Abstract/448101
ISSN: 16616758
Appears in Collections:DENCS - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_HigherFruitIntakes.pdf582,74 kBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.