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Title: The role of lymph node revealing solution on the improvement of lymph node harvest in colorectal cancer specimens.
Authors: Profeta da Luz, Magda Maria
Lacerda Filho, A.
Cabral, Mônica Maria Demas Álvares
Fonseca, Leonardo Maciel da
Araújo, Stanley de Almeida
Sanches, Soraya Rodrigues de Almeida
Silva, R. Gomes da
Keywords: Staging
Issue Date: 2016
Citation: PROFETA DA LUZ, M. M. et al. The role of lymph node revealing solution on the improvement of lymph node harvest in colorectal cancer specimens. 2016. Colorectal Disease, v. 18, p. 247-254, 2016. Disponível em: <>. Acesso em: 05 ago. 2017.
Abstract: Aim The correct analysis of lymph node status is one of the most important parameters for the accurate pathological diagnosis of colorectal cancer. Our aim was to evaluate the number of lymph nodes among the specimens obtained from colorectal resections due to colorectal cancer, before and after the routine use of a lymph node revealing solution (LNRS). Method Data from 780 surgical specimens from patients of both genders with colorectal cancer were studied. The cases were divided chronologically into two groups: the conventional group included 497 specimens treated with conventional methods, i.e. without the use of the LNRS (January 2000 to July 2007), and the LNRS group included 283 specimens examined through the routine use of this solution (August 2007 to July 2012). Results Most patients were female (57.4%) with a median age of 62 years. The median lymph node number was 18, and 75.9% of the cases (592) had 12 or more nodes dissected. Lymph node metastases were noted in 334 cases (42.8%). A median of 24 lymph nodes was dissected in the LNRS group compared to 15 in the conventional group (P < 0.001). The LNRS group had 9.2% of cases with fewer than 12 lymph nodes dissected compared with 32.6% in the conventional group (P < 0.001). Conclusions The use of the LNRS increases the number of lymph nodes obtained from colorectal cancer surgical specimens and can help to reduce the number of cases with < 12 lymph nodes.
ISSN: 14631318
Appears in Collections:DECPA - Artigos publicados em periódicos

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