Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/892
Title: Cytokine and transcription factor profiles in the skin of dogs naturally infected by Leishmania (Leishmania) chagasi presenting distinct cutaneous parasite density and clinical status.
Authors: Souza, Daniel Menezes
Oliveira, Rodrigo Corrêa de
Cota, Renata Guerra de Sá
Giunchetti, Rodolfo Cordeiro
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Oliveira, Guilherme Corrêa de
Reis, Alexandre Barbosa
Keywords: Canine visceral leishmaniasis
Cytokines
Transcription factor
Leishmania chagasi
Parasitism
Issue Date: 2011
Citation: SOUZA, D. M. et al. Cytokine and transcription factor profiles in the skin of dogs naturally infected by Leishmania (Leishmania) chagasi presenting distinct cutaneous parasite density and clinical status. Veterinary Parasitology, v.177, p. 39-49, 2011. Disponível em: <https://www.sciencedirect.com/science/article/pii/S030440171000662X>. Acesso em: 18 jun. 2012.
Abstract: The immune response in the skin of dogs infected withLeishmania chagasi and its asso-ciation with distinct levels of tissue parasitism and clinical progression of canine visceral leishmaniasis (CVL) are poorly understood and limited studies are available. A detailed analysis of the profiles of cytokines (IFN- , IL-4, IL-5, IL-10, IL-12, IL-13, TGF- 1 and TNF- ) and transcription factors (T-bet, GATA-3 and FOXP3) in the skin of 35 naturally infected dogs was carried out using real-time PCR alongside determinations of skin parasite density and the clinical status of CVL. A mixed cytokine profile with high levels of expression of IFN- , TNF- and IL-13 was determined in asymptomatic dogs. Additionally, the levels of transcription factors GATA-3 and FOXP3 were correlated with the asymptomatic disease. A mixed cytokine profile was also observed during active CVL. Moreover, high levels of IL-10 and TGF- 1, concomitant with the low expression of IL-12, may represent a key condition that allows persistence of parasite replication in the skin. The results obtained indicate that in asymptomatic disease or lower levels of skin parasite density, a mixed inflammatory, regulatory immune response profile may be of major relevance for both the maintenance of the clinical status of the dogs as well as for parasite persistence and replication at low levels.
URI: http://www.repositorio.ufop.br/handle/123456789/892
ISSN: 03044017
metadata.dc.rights.license: O Periódico Veterinary Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3287140946746.
Appears in Collections:DEACL - Artigos publicados em periódicos

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