Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/8890
Title: Development and validation of an analytical method for quantification of arsenic and antimony in liposomes using inductively coupled plasma-optical emission spectrometry.
Authors: Reis, Priscila Gomes dos
Abreu, Adriana Trópia de
Guimarães, Andrea Grabe
Teixeira, Mônica Cristina
Souza, Jacqueline de
Barcellos, Neila Marcia Silva
Issue Date: 2013
Citation: REIS, P. G. dos et al. Development and validation of an analytical method for quantification of arsenic and antimony in liposomes using inductively coupled plasma-optical emission spectrometry. Journal of AOAC International, v. 96, p. 771-775, 2013. Disponível em: <http://aoac.publisher.ingentaconnect.com/contentone/aoac/jaoac/2013/00000096/00000004/art00018>. Acesso em: 06 out. 2017.
Abstract: Arsenic and antimony compounds are used to treat endemic diseases, such as cancer, leishmaniasis, and schistosomiasis, in spite of their toxicity. Several studies seeking the development and characterization of nanocarrier systems such as liposomes are being carried out with the aim of developing new drug delivery systems and minimizing the toxicity of these drugs. However, the lack of reference methods to quantify these semimetals within a liposomal matrix hinders the QC of these formulations. Therefore, the validation of an analytical method for arsenic and antimony quantification in liposomal matrix by inductively coupled plasma-optical emission spectrometry is presented here. The linearity, specificity, LOD, LOQ, accuracy, and precision were determined according to the International Conference on Harmonization norms and the Brazilian Health Surveillance Agency (Resolution 899). The LOD values were 0.02 and 0.06 mg/L for antimony and arsenic, respectively. The LOQ for both was 3.0 mg/L, with an adequate accuracy within 98.26 and 101.32% for different levels of antimony and 99.98 and 100.36% for arsenic. Precision (CV) was lower than 5.0%. The developed and validated method was shown to be reproducible for quantification of arsenic and antimony in liposome pharmaceutical dosage forms.
URI: http://www.repositorio.ufop.br/handle/123456789/8890
metadata.dc.identifier.uri2: http://aoac.publisher.ingentaconnect.com/contentone/aoac/jaoac/2013/00000096/00000004/art00018
metadata.dc.identifier.doi: https://doi.org/10.5740/jaoacint.10-263
ISSN: 1944-7922
Appears in Collections:DEFAR - Artigos publicados em periódicos

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