Please use this identifier to cite or link to this item:
Title: Clustered cardiovascular risk factors are associated with inflammatory markers in adolescents.
Authors: Silva, Carla Teixeira
Cândido, Ana Paula Carlos
Pala, Daniela
Barbosa, Priscila Oliveira
Coelho, George Luiz Lins Machado
Oliveira, Fernando Luiz Pereira de
Volp, Ana Carolina Pinheiro
Freitas, Renata Nascimento de
Keywords: Cytokines
Cardiovascular disease - risk factors
Principal components analysis
Issue Date: 2017
Citation: SILVA, C. T. et al. Clustered cardiovascular risk factors are associated with inflammatory markers in adolescents. Annals of Nutrition and Metabolism, v. 70, p. 259-267, 2017. Disponível em: <>. Acesso em: 29 ago. 2017.
Abstract: Background: Clusters of cardiovascular risk (CVR) factors are associated with an increased risk of developing cardiovascular diseases (CVDs). This cross-sectional study assessed the associations between classic CVR factor clusters and inflammatory markers in Brazilian adolescents. Methods: Measurements included anthropometric, clinical and biochemical parameters and selected inflammatory markers in 487 adolescents (236 boys/251 girls; 12.06 ± 1.41 years). Results: After stratifying the population by gender and adjusting for potential confounding variables, principal component analysis was performed and it produced 5 independent components in both genders: adiposity, glucose metabolism, blood pressure, high-density lipoprotein (HDL)/triacylglycerols (TG), and cholesterol/low-density lipoprotein. Glucose metabolism was inversely associated with interleukin-1β (IL-1β) in both genders ( r = –0.026; r = –0.021); blood pressure was inversely associated with tumor necrosis factor alpha (TNF-α) in girls ( r = –0.046); HDL/TG was positively associated with interleukin-6 in girls ( r = 0.012), with IL-1β ( r = 0.010) TNF-α ( r = 0.045) in boys, and inversely associated with adiponectin in both genders ( r = –0.015; r = –0.013). Conclusion: The results suggest that lipid metabolism alterations, as potential early events in the development of CVDs, have a strong link to the inflammatory process, in contrast to other clusters of risk factors.
ISSN: 1421-9697
Appears in Collections:DEMSC - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
  Restricted Access
133,68 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.